A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

By Yongzhong Liu, Pin Zhang, Jun Li, A. Kulkarni, S. Perruche, Wanjun Chen. Nature Immunology, 2008

609 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/3a0bd4d591f073e0f28123b9c8712db0c456a2ee

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In Immunology

Citations in the corpus

The PD-1 Pathway in Tolerance and Autoimmunity (2010, background): “However, it is still unclear whether TGF-b functions as a suppressor molecule utilized by Tregs (70, 101, 102).”
TGF-β Activation and Function in Immunity (2013, background): “were almost completely absent for the first 5 days after birth (25).”
Mechanisms of foxp3+ T regulatory cell-mediated suppression. (2009, background): “…Development, Homeostasis, and Effector Function Although TGF-b plays a critical role in the induction of Foxp3+ Treg cell in vivo and in vitro (Chen et al., 2003; Liu et al., 2008) and in Treg cell homeostasis (Marie et al., 2005), its role as a suppressor effector molecule remains controversial.”
Transforming Grown Factor-β Signaling in Immunity and Cancer (2019, positive): “…of the CD4 promoter (Gorelik and Flavell, 2000) or bearing T cell-specific deletion of either Tgfbr2 (Li et al., 2006; Marie et al., 2006), Tgfbr1 (Liu et al., 2008) or Tgfb1 (Li et al., 2007) by means of a CD4-Cre driver, develop enhanced T cell activation leading to a severe inflammatory…”
Control of regulatory T cell lineage commitment and maintenance (2009, background): “In support of this notion, ablation of the TGF-bRI subunit in DP thymocytes resulted in a profound but transient impairment in generation of Foxp3 Treg cells during the first week of life followed by the recovery of Foxp3 thymocyte numbers to those observed in wild-type mice (Liu et al., 2008).”
Regulatory T Cells: Mechanisms of Differentiation and Function (2012, background): “The rebound of tTreg cells was attributed to compensation of TGF-β signaling deficiency by age-dependent increases in IL-2 levels (95).”
TGF-beta: a master of all T cell trades. (2008, positive): “showed that this loss of TGF-βRI blocked nTreg cell differentiation in 3- to 5-day-old mice but triggered nTreg cell expansion in mice older than 1 week (Liu et al., 2008).”