Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion: Roles of AMP-Activated Protein Kinase and Beclin 1 in Mediating Autophagy

By Y. Matsui, H. Takagi, X. Qu, M. Abdellatif, H. Sakoda, T. Asano, Beth Levine, J. Sadoshima. Circulation Research, 2007

1,528 citations recorded by the source corpus.

Subfields: Epidemiology, Neurology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/fa96f6af0c394a32fe98bef0ed5c403b19ff2439

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Citations in the corpus

Pathophysiology of Myocardial Infarction (2015, positive): “Myocardial ischemia induces a robust stimulation of autophagy in cardiomyocytes mediated through an AMP-activated protein kinase (AMPK)-dependent pathway (245).”
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. (2008, result): “Similar phenomenon was observed previously in Beclin 1-silenced mammalian cells (Zeng et al., 2006; Matsui et al., 2007) and FIP200 deficient cells (Hara et al., 2008).”
Pathogenesis of Myocardial Ischemia-Reperfusion Injury and Rationale for Therapy (2010, positive): “This may be articularly important, as microvascular plugging with eukocytes and platelet “debris” has been implicated as n important component of the IR process.41,42 Another omplexity relates to patient co-morbidities that influence he myocardial substrate during IR.”
Ischemia/Reperfusion (2016, positive): “acids for maintenance of cell function or by removing damaged organelles, oxidized proteins, and protein aggregates (115, 331, 390, 539, 540, 698) (Fig.”
Autophagy: process and function. (2007, background): “2006) and in ischemic myocardium (Yan et al. 2005; Matsui et al. 2007).”
Cardiac autophagy is a maladaptive response to hemodynamic stress. (2007, background): “Recently, cardiac autophagy was reported in models of short-term nutrient deprivation (15, 19, 20), chronic ischemia (33), diphtheria toxin–induced injury (34), and ischemia-reperfusion injury (35, 36).”
AMPK Activates Autophagy by Phosphorylating ULK1 (2011, neutral): “ischemia, which is Beclin 1-dependent and AMPKindependent, might play a negative role for cell survival.(10) Understanding the mechanism by which AMPK-activated”
Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells (2008, background): “Oxidative stress has been shown to induce autophagy under starvation and ischemia/reperfusion conditions.(12,13) Under oxidative stress, reactive oxygen species (ROS) including free radicals such as superoxide (O2 d ), hydroxyl radical (HO d ) and hydrogen peroxide (H2O2) are generated at high level”
Autophagy and Mitophagy in Cardiovascular Disease. (2017, background): “In agreement with this view, it has been reported that Becn1 mice—which are characterized by a partial autophagic defect at the whole-body level—are more resistant to cardiac damage at reperfusion than their WT littermates.(65) It has also been shown that intravenous administration of a miR188-3p–co”
Molecular mechanisms of diabetic cardiomyopathy (2014, neutral): “AMPK activation inhibits MTOR and can therefore activate autophagy [112].”