Pathogenesis of Myocardial Ischemia-Reperfusion Injury and Rationale for Therapy
By A. Turer, Joseph A. Hill. American Journal of Cardiology, 2010
636 citations recorded by the source corpus.
Since the initial description of the phenomenon by Jennings et al 50 years ago, our understanding of the underlying mechanisms of reperfusion injury has grown significantly. Its pathogenesis reflects the confluence of multiple pathways, including ion channels, reactive oxygen species, inflammation, and endothelial dysfunction. This complexity should not deter our efforts to intervene in this process, however, since nearly 2 million patients annually undergo either spontaneous (in the form of acute myocardial infarction) or iatrogenic (in the context of cardioplegic arrest) ischemia-reperfusion. The purpose of this review is to examine our current state of understanding of ischemia-reperfusion injury and highlight recent interventions aimed at this heretofore elusive target.
Subfields: Developmental Neuroscience, Emergency Medicine, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/796f71801df4b760eac148cf97b272f26ee30c00
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Citations in the corpus
- Cell Biology of Ischemia/Reperfusion Injury (2012, background): “In the cardiac field, many of the initial pilot successes with preconditioning were not subsequently confirmed in larger trials (Turer and Hill, 2010; Yellon and Hausenloy, 2007).”
- Ischemia/Reperfusion (2016, neutral): “als indicated that such conditioning-based approaches might improve clinical outcomes (16, 126, 823, 834), larger trials have failed to confirm efficacy (399, 614, 645, 796, 881).”