Molecular mechanisms of diabetic cardiomyopathy

By H. Bugger, E. Dale Abel. Diabetologia, 2014

865 citations recorded by the source corpus.

In recent years, diabetes mellitus has become an epidemic and now represents one of the most prevalent disorders. Cardiovascular complications are the major cause of mortality and morbidity in diabetic patients. While ischaemic events dominate the cardiac complications of diabetes, it is widely recognised that the risk for developing heart failure is also increased in the absence of overt myocardial ischaemia and hypertension or is accelerated in the presence of these comorbidities. These diabetes-associated changes in myocardial structure and function have been called diabetic cardiomyopathy. Numerous molecular mechanisms have been proposed to contribute to the development of diabetic cardiomyopathy following analysis of various animal models of type 1 or type 2 diabetes and in genetically modified mouse models. The steady increase in reports presenting novel mechanistic data on this subject expands the list of potential underlying mechanisms. The current review provides an update on molecular alterations that may contribute to the structural and functional alterations in the diabetic heart.

Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/30a313a536db0c45a15c2cfe834399216df6413d

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In Molecular Biology

1. Michael Pollak
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2. B. Viollet

Citations in the corpus

• Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus (2016, background): “Increased MYCL is one of the many potential pathophysiologic mechanisms implicated in “diabetic cardiomyopathy” (225).”
• Metformin: from mechanisms of action to therapies. (2014, background): “…atherosclerosis of large arteries and coronary atherosclerosis, which contributes to not only diabetes-related mortality and morbidity but also includes diabetic cardiomyopathy, a specific heart muscle dysfunction that occurs independently of coronary artery disease (Bugger and Abel, 2014).”
• Mitochondrial dynamics in health and disease: mechanisms and potential targets (2023, background): “Structure and function abnormalities of the heart, causing diabetes-related cardiomyopathy (DCM), are commonly associated with diabetes.(228) Specifically, for db/db mice, diabetes-induced hearts exhibite increased mitochondrial fission accompanied by a significantly lower expression of MFN2.”