Cardiac autophagy is a maladaptive response to hemodynamic stress.
By Hongxin Zhu, P. Tannous, Janet L. Johnstone, Y. Kong, J. Shelton, J. Richardson, V. Le, Beth Levine, B. Rothermel, Joseph A. Hill. Journal of Clinical Investigation, 2007
757 citations recorded by the source corpus.
Subfields: Demography, Epidemiology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/b6143c3c82fa568206bb5749595f049cf806b7bf
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Epidemiology
- D. Klionsky
- Beth Levine
- N. Mizushima
- Guido Kroemer
- I. Slaninová
- V. Deretic
- Alec C. Kimmelman
- D. Rubinsztein
In Molecular Biology
- Beth Levine
- D. Klionsky
- N. Mizushima
- V. Deretic
- Guido Kroemer
- Alec C. Kimmelman
- M. Komatsu
- Eric H. Baehrecke
Citations in the corpus
- Autophagy: Renovation of Cells and Tissues (2011, background): “Paradoxically, heterozygous deletion of Beclin 1, which partially reduces autophagic activity, improves cardiac function upon pressure overload (Zhu et al., 2007).”
- Cardiac Metabolism in Heart Failure - Implications beyond ATP production (2013, neutral): “knockout models with suppressed autophagy have delivered inconsistent results.(119,120) Given the highly complex regulation”
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, neutral): “In addition, tissue-specific GFPLC3 mice have been generated for monitoring cardiac myocytes.(951,952) In these settings, GFP fluorescent puncta are indicative of autophagic structures; however, the use of a lysosomal fusion or protease inhibitor would be needed to assess flux.”
- Molecular mechanisms of diabetic cardiomyopathy (2014, neutral): “For example, activation of autophagy is protective during ischaemia, when energy depletion occurs [112], whereas it may bemaladaptive in the load-stressed heart and during postischaemic reperfusion [111, 112].”
- Guidelines for the use and interpretation of assays for monitoring autophagy (2012, background): “In addition, tissue-specific GFP-LC3 mice have been generated for monitoring cardiac myocytes.(629,630) In these settings, GFP fluorescent puncta are indicative of autophagic structures.”