Intranasal insulin improves cognition and modulates β-amyloid in early AD

By M. Reger, G. S. Watson, P. Green, C. Wilkinson, L. Baker, B. Cholerton, S. Plymate, J. Breitner, W. DeGroodt, P. Mehta and 1 more. Neurology, 2008

779 citations recorded by the source corpus.

Subfields: Molecular Biology, Pharmaceutical Science, Physiology

View Paper: https://www.semanticscholar.org/paper/f91d9738c2cc28ae23e53906a6b821c7af6aadc9

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Citations in the corpus

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies. (2013, background): “…shown to improve memory and attention abilities without significant adverse effects as well as changes in blood levels of insulin or glucose (Benedict et al., 2008; Craft et al., 2012; Dhamoon et al., 2009; Djupesland, 2008; Reger et al., 2006, 2008a,b; Schioth et al., 2012; Shemesh et al., 2012).”
Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease (2014, background): “Intranasal insulin administration, a preferential route for CNS delivery, improves memory in healthy adults without affecting circulating levels of insulin or glucose (89).”
Epidemiology of Alzheimer Disease (2012, positive): “Reger et al. (2008) showed that the administration of intranasal insulin improved cognitive performance in the early phases of AD and in patients with amnestic mild cognitive impairment , as did a 6-month trial of the PPAR-g agonist , rosiglitazone (Watson et al. 2005).”
The many faces of insulin-like peptide signalling in the brain (2012, background): “As a consequence, changes in ILP levels in the brain affect arousal, spatial memory and associative conditioning in mammal”
Intranasal delivery to the central nervous system: mechanisms and experimental considerations. (2010, background): “Intranasal insulin dose-dependently improves memory after acute treatment,(21,22) and improves attention, memory, and cognitive function after 21 days of intranasal treatment.(23) In addition to insulin, other peptides and proteins administered by the intranasal route are proving to have beneficial ”
Intranasal delivery of biologics to the central nervous system. (2012, background): “In patients with amnesic mild cognitive impairment IN insulin modulated plasma levels of Aβ and improved memory, attention, and functional status, suggesting a possible role for IN delivery of insulin in the treatment of Alzheimer's disease [145].”
Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers (2009, background): “Recent studies have shown that intranasal administration of insulin improves memory in both nondemented humans and in AD patients (30, 40).”