The many faces of insulin-like peptide signalling in the brain
By Ana M Fernandez, I. Torres-Alemán. Nature Reviews Neuroscience, 2012
849 citations recorded by the source corpus.
Subfields: Endocrine and Autonomic Systems, Genetics, Surgery
View Paper: https://www.semanticscholar.org/paper/35690500afc4f746f6f5099563125ee387e7824c
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Citations in the corpus
- Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults (2016, background): “IGF-I, which is mainly known for its role in energy metabolism and homeostasis, is emerging as a key growth factorwhich alsomodulates synaptic plasticity, synapse density, neurotransmission, and even adult neurogenesis (e.g., Fernandez and Torres-Alemán, 2012; Trejo et al., 2007).”
- Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models (2019, methodology): “Three complementary lines of evidence indicate the specificity of the anti-FNDC5 antibody and ELISA kit used in the current work: (1) FNDC5/irisin levels detected by ELISA showed the expected increase or decrease, respectively, when FNDC5/irisin was overexpressed by use of an adenoviral vector (in b”
- Insulin Action in Brain Regulates Systemic Metabolism and Brain Function (2014, background): “In lower organisms, like Caenorhabditis elegans and Drosophila, insulin-like peptides not only are produced in neurons, but neurons are the primary source of these peptides (3).”
- Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease (2014, background): “factor (85), possibly by activating either its own receptor or IGF receptors (86).”
- Rett Syndrome and Fragile X Syndrome: Different Etiology With Common Molecular Dysfunctions (2021, background): “Pre-Pro-BDNF is concentrated at the endoplasmic reticulum before becoming pro-BDNF at the Golgi apparatus (Foltran and Diaz, 2016).”