Epidemiology of Alzheimer Disease

By Richard P. Mayeux, Yaakov Stern. Cold Spring Harbor Perspectives in Medicine, 2012

1,774 citations recorded by the source corpus.

The global prevalence of dementia has been estimated to be as high as 24 million, and is predicted to double every 20 years until at least 2040. As the population worldwide continues to age, the number of individuals at risk will also increase, particularly among the very old. Alzheimer disease is the leading cause of dementia beginning with impaired memory. The neuropathological hallmarks of Alzheimer disease include diffuse and neuritic extracellular amyloid plaques in brain that are frequently surrounded by dystrophic neurites and intra-neuronal neurofibrillary tangles. The etiology of Alzheimer disease remains unclear, but it is likely to be the result of both genetic and environmental factors. In this review we discuss the prevalence and incidence rates, the established environmental risk factors, and the protective factors, and briefly review genetic variants predisposing to disease.

Subfields: Health, Toxicology and Mutagenesis, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/10945c6ee44d86a3e3238b360f4a6ec21a1d5072

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In Physiology

1. Thomas J. Montine
2. D. Nathan
3. Michael D. Geschwind
4. Michael G. Erkkinen
5. Mee‐Ohk Kim

In Psychiatry and Mental health

1. Thomas J. Montine
2. Michael D. Geschwind
3. Michael G. Erkkinen
4. Mee‐Ohk Kim

Citations in the corpus

• Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases. (2018, background): “AD is the most common form of dementia worldwide and makes up 60%–80% of all dementia cases, affecting an estimated 24 million people globally (Reitz et al. 2011; Mayeux and Stern 2012; Sosa-Ortiz et al. 2012).”
• Glucose Levels and Risk of Dementia (2013, background): “org august 8, 2013 541 W ith the aging of the population, dementia has become a major threat to public health worldwide.(1) The rate of obesity is also increasing, with a parallel increase in the rate of diabetes.”
• 2013 Alzheimer's disease facts and figures (2013, neutral): “A pattern that has emerged from these findings, taken together, is that dementia risk may increase with the presence of the metabolic syndrome, a collection of conditions occurring together—specifically, three or more of the following: hypertension, high blood glucose, central obesity (obesity in wh”
• Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences (2014, neutral): “Introduction Alzheimer’s disease (AD) is the most prevalent type of dementia, comprising about 60%–70% of all dementia cases.(1) Beta-amyloid plaques, neurofibrillary tangles, and”
• Religious Orders Study and Rush Memory and Aging Project (2018, neutral): “In addition, like others we find that cognitive function and many risk factors for AD are also related to change in motor structure and function [411, 412].”