Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

By Edward A. Miao, C. Alpuche-Aranda, Monica Dors, April E. Clark, M. Bader, Samuel I. Miller, Alan Aderem. Nature Immunology, 2006

1,207 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/f7e4d14e4c03924732c599f3d1365ead85c2a770

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In Cell Biology

1. J. Tschopp
2. Fabio Martinon
3. T. Mak

In Molecular Biology

1. T. Kanneganti
2. M. Lamkanfi
3. J. Tschopp
4. G. Núñez
5. V. Dixit
6. S. Man
7. L. Franchi
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In Nutrition and Dietetics

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Citations in the corpus

• NF-κB and the immune response (2006, background): “Recent articles have demonstrated TLR5-independent recognition of cytosolic Salmonella typhimurium flagellin via Ipaf, a member of the NODLRR family (Franchi et al., 2006; Miao et al., 2006).”
• The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases (2011, background): “Intracellular flagellin was first shown to activate the NLRC4 inflammasome (88, 89).”
• Pyroptotic cell death defends against intracellular pathogens (2015, background): “typhimurium strains deficient in flagellin expression still trigger NLRC4, indicating that NLRC4 is capable of responding to additional agonists (20).”
• Mechanisms and functions of inflammasomes. (2014, background): “…components of pathogenic bacteria: flagellin, the building block of their locomotion machinery, and proteins from the type III and IV bacterial secretion systems that inject virulence factors into the host cell (Amer et al., 2006; Franchi et al., 2006; Miao et al., 2006; Miao et al., 2010b).”
• Inflammatory caspases and inflammasomes: master switches of inflammation (2007, background): “They could show that S. typhimurium with a deficient flagellin does not stimulate caspase-1 or IL-1b secretion, and that intracellular flagellin activates an IPAF inflammasome,100,101 a mechanism that does not require the other flagellin sensor TLR5.”
• Regulation of inflammasome activation (2015, background): “The mouse NLRC4 inflammasome is activated by flagellin (124, 125) and the inner rod proteins of the Type III secretion system of S.”
• Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria (2010, background): “typhimurium is able to evade detection by NLRC4 during the systemic phase of infectio”
• Function of Nod‐like receptors in microbial recognition and host defense (2009, background): “Caspase1 is essential for the early induction of cell death, membrane swelling, and IL-1b production in macrophages infected with Salmonella (149, 215), Pseudomonas (154), Shigella (152), Listeria (216), Legionella (155), or when macrophages are stimulated with anthrax LT (217) or with ATP (218, 219”