Inflammatory caspases and inflammasomes: master switches of inflammation

By Fabio Martinon, J. Tschopp. Cell Death and Differentiation, 2007

815 citations recorded by the source corpus.

Subfields: Molecular Biology, Nutrition and Dietetics, Surgery

View Paper: https://www.semanticscholar.org/paper/4d45300b733f8a9b7359d59efc27c85c1db914c3

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Citations in the corpus

Function of Nod‐like receptors in microbial recognition and host defense (2009, background): “Upon stimulation by a variety of microbial and endogenous signals, the dormant pro-caspase-1 molecule is self-activated by proteolytic cleavage into the enzymatically active heterodimer composed of a 10- and a 20-kDa chain (135, 136) (Fig.”
NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases (2015, background): “…Univ Paris 06, UMR 8256, Biological Adaptation and Ageing - IBPS, F-75005 Paris, France b CNRS-UMR 8256, F-75005 Paris, France c Inserm U1164, F-75005 Paris, France d Institute of Pharmacology of Natural Products & Clinical Pharmacology, Ulm University, D-89081 Ulm, Germany a r t i c l e i n f o”
The inflammasomes. (2010, positive): “The proinflammatory caspases are comprised of caspase-1, -11 and -12 in mouse and caspase-1, -4, and -5 in human (Martinon and Tschopp, 2007).”
Classification of cell death (2005, neutral): “relevant role in both local and systemic inflammatory reactions.(80,81) As it stands, macrophages undergoing pyroptosis not only exhibit morphological features that are”
Molecular Pathogenesis of Shigella spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion (2008, background): “Extensive research over the last years described the inflammasome as being a dynamic multiprotein complex (160, 162).”
Programmed cell death in the plant immune system (2011, background): “Remarkably, the first caspase discovered in mammals was the IL-1b-converting enzyme (ICE), later known as caspase-1, which does not participate in apoptosis, but does control inflammation and pyroptotic cell death (see below) downstream of NLR activation.(8,29) During the last decade, an increasing ”
ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells (2019, background): “NLR family members, NACHT lectin-like receptor and PYD domain-containing proteins (NLRPs), promote the assembly of inflammasomes and mediate the activation of inflammatory caspases [166].”
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration (2007, background): “Through its CARD domain, IPAF directly binds and activates caspase-1.(6) Signals and mechanisms leading to inflammasome activation are still poorly understood.”
The inflammasomes: guardians of the body. (2009, background): “NLRs are characterized by three distinct domains: the ligand-sensing leucine-rich repeats (LRRs); the NACHT domain, which is responsible for the capacity of NLRs to oligomerize; and the effector domain, which can be a pyrin domain (PYD), CARD, or BIR domain.”