Mechanisms and functions of inflammasomes.

By M. Lamkanfi, V. Dixit. Cell, 2014

2,315 citations recorded by the source corpus.

Subfields: Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/79158613cbc7bb0326af3126b7f28b02ade126ca

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. T. Kanneganti
2. M. Lamkanfi
3. S. Man
4. G. Núñez
5. Yuan He
6. V. Dixit
7. H. Hara
8. V. Deretic

In Surgery

1. T. Kanneganti
2. V. Deretic
3. G. Hajishengallis
4. S. Man
5. M. Lamkanfi
6. G. Núñez
7. V. Dixit
8. Jonathan D. G. Jones

Citations in the corpus

• Periodontitis: from microbial immune subversion to systemic inflammation (2014, background): “This mechanism may promote the fitness of the periodontal community since inflammasome activation induces pyroptosis, a proinflammatory mode of lytic cell death protecting the host against infection 76 .”
• Autophagy in inflammation, infection, and immunometabolism (2021, background): “Autophagy has been shown to be induced by eIF2α kinase PKR (EIF2AK2), which recognizes dsRNA in the context of infection by a variety of DNA and RNA viruses, as a part of innate response (Talloczy et al., 2002).”
• Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke. (2016, background): “mediated by the inflammasome and caspase family of proteins (Jimenez Fernandez and Lamkanfi, 2015; Lamkanfi and Dixit, 2014; Macchi et al., 2015).”
• New developments in goblet cell mucus secretion and function (2015, neutral): “These are multiprotein complexes that typically comprise one of the NOD-like receptor (NLR) family members linked to an inflammatory caspase, such as Caspase 1, via interactions with the adapter protein ASC (apoptosis-associated speck-like protein containing a CARD).(39) NLRPs are thought to functio”
• Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. (2016, background): “Gramnegative bacteria and intracellular LPS trigger a non-canonical pathway that results in caspase-11-dependent IL-1b secretion and pyroptotic cell death (Lamkanfi and Dixit, 2014).”
• The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation (2019, background): “There are five members of PRRs that have been confirmed to form inflammasomes: the nucleotide-binding oligomerization domain (NOD), leucine-rich repeat (LRR)-containing proteins (NLR) family members NLRP1, NLRP3, and NLRC4, as well as absent-in-melanoma 2 (AIM2) and pyrin [3,4].”
• Mechanism and regulation of NLRP3 inflammasome activation (2016, background): “To date, five PRRs (NLRP1, NLRP3, NLRC4, Pyrin, and AIM2) have been shown to form inflammasomes [6,7].”
• Human Monocytes Engage an Alternative Inflammasome Pathway. (2016, neutral): “, via Toll-like receptor (TLR) signaling, whereas a second signal (signal 2) is recognized in order to activate the inflammasome (Guo et al., 2015; Lamkanfi and Dixit, 2014; Latz et al., 2013; Wen et al., 2013).”