Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial.

By L. Heilbronn, L. de Jonge, M. Frisard, J. DeLany, D. Larson-Meyer, J. Rood, T. Nguyen, Corby K. Martin, J. Volaufova, Marlene M. Most and 6 more. Journal of the American Medical Association (JAMA), 2006

965 citations recorded by the source corpus.

Subfields: Aging, Pediatrics, Perinatology and Child Health, Physiology

View Paper: https://www.semanticscholar.org/paper/f7df812cc0a7571791ae0fdd7bce4cdc01af1b8b

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Citations in the corpus

American College of Sports Medicine Position Stand. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. (2009, background): “When the energy deficit imposed by diet-only and diet plus PA interventions are similar, weight loss and/or percent change in body weight are similar (4,8,18,39, 58,59,72,82,103,120,140).”
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan (2008, neutral): “Although DR has beneficial effects in humans (Heilbronn et al., 2006), such a diet is unlikely to be widely adopted, and would pose a significant risk to the frail, critically ill, or the elderly.”
Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. (2007, background): “Other authors have reported modest or nonsignificant changes in levels of protein carbonyls with various CR regimes [41] [42] [43].”
How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis). (2010, background): “Hence and due to additional findings (Fontana et al., 2004; Heilbronn et al., 2006; Ingram et al., 2006a; Weindruch, 2006; Fontana and Klein, 2007) it appears possible that CR extends life span in primates and/or humans.”
Promoting Health and Longevity through Diet: from Model Organisms to Humans (2015, positive): “In short-term, randomized clinical trials in aging humans, DR improves several markers of health (Heilbronn et al., 2006; Fontana et al., Handbook, 2010).”
Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans (2011, neutral): “The selected cohort consisted of 18 lean members of the Calorie Restriction Society who typically measure and record all components of their diets on a daily basis with computer software to insure optimal nutrition despite reduced energy intake (14,15).”
An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. (2007, background): “Some studies suggest that health benefits can be manifested from short-term reductions in caloric intake (68, 99, 274, 275), but there are currently no results from well-controlled studies involving long-term CR.”
Quantification of the effect of energy imbalance on bodyweight (2011, neutral): “C shows our model simulations of weight change and body fat change along with experimental data from the CALERIE study 80 that investigated 6 months of 25% caloric restriction, 12·5% caloric restriction plus exercise, and 3 months of a liquid diet of 3·7 MJ per day followed by a period of weight…”
Calorie restriction-like effects of 30 days of Resveratrol (resVida™) supplementation on energy metabolism and metabolic profile in obese humans (2011, background): “Although short-term dietary restriction has metabolic effects in humans such as lowering metabolic rate (Heilbronn et al., 2006), improving insulin sensitivity (Larson-Meyer et al., 2006; Lim et al., 2011), and reducing cardiovascular risk factors (Lefevre et al., 2009), eating less for the sake of…”
FOXO3A genotype is strongly associated with human longevity (2008, background): “In vivo studies show that oxidative lesions in DNA, proteins, and other tissues accumulate with age and feeding calorically restricted diets (a potent insulin sensitizer) to rodents (56) and humans (57) mitigates this damage.”