FOXO3A genotype is strongly associated with human longevity

By B. Willcox, T. Donlon, Qimei He, Randi Chen, J. Grove, K. Yano, K. Masaki, D. Willcox, B. Rodríguez, J. Curb. Proceedings of the National Academy of Sciences of the United States of America, 2008

992 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/156cb1f051d33f4289bcfe263e15a47e6df0fc5c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. Rute Martins
2. W. Link
3. G. Lithgow

In Molecular Biology

1. Stefan Schreiber
2. Fred H. Gage
3. J. Gonçalves
4. M. Hetzer
5. Emily M. Hatch
6. Hongjun Song

In Physiology

1. Rute Martins
2. Fred H. Gage
3. W. Link
4. G. Lithgow

Citations in the corpus

• Long live FOXO: unraveling the role of FOXO proteins in aging and longevity (2015, background): “Among these, only the rs2764264, rs13217795, and rs2802292 FOXO3A SNPs stood out as they were found to be associated with longevity and healthy aging (Willcox et al., 2008).”
• Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects (2015, positive): “For example, genetic polymorphisms within the FOXO3 gene have been associated with human longevity (Flachsbart et al., 2009; Willcox et al., 2008).”
• Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates (2012, neutral): “As genetic associations have been previously reported with human longevity and aging phenotypes (Atzmon et al., 2006; Suh et al., 2008; Willcox et al., 2008; Wheeler et al., 2009), we examined whether the model could distinguish aging rates for individuals with different genetic variants.”
• Association of FOXO3A variation with human longevity confirmed in German centenarians (2009, methodology): “’s (12) rs2802292 (according to CEU HapMap data),”
• Insulin Action in Brain Regulates Systemic Metabolism and Brain Function (2014, background): “Also, genetic variation within the FoxO3a gene, a transcription factor downstream of the IR, is associated with human longevity (123), but how this relates to central insulin signaling is unknown.”