Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan

By Kevin J. Pearson, Joseph A. Baur, Kaitlyn N. Lewis, Leonid Peshkin, Nathan L. Price, N. Labinskyy, W. Swindell, D. Kamara, R. Minor, Evelyn Perez and 17 more. Cell Metabolism, 2008

1,185 citations recorded by the source corpus.

SUMMARY A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related diseases in laboratory animals is greatly sought after. We and others have shown that resveratrol mimics effects of DR in lower organisms. In mice, we find that resveratrol induces gene expression patterns in multiple tissues that parallel those induced by DR and every-other-day feeding. Moreover, resveratrol-fed elderly mice show a marked reduction in signs of aging including reduced albuminuria, decreased inflammation and apoptosis in the vascular endothelium, increased aortic elasticity, greater motor coordination, reduced cataract formation, and preserved bone mineral density. However, mice fed a standard diet did not live longer when treated with resveratrol beginning at 12 months of age. Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started mid-life.

Subfields: Aging, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/2d9501b748927b50f6ddbb1e90cb140c1e989551

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Citations in the corpus

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010, positive): “Resveratrol, an ingredient in red wines, is a polyphenolic SIRT1 activator that, like calorie restriction, has anti-aging effects in lower organisms (22, 143, 331), reduces signs of aging in mice (248), and extends survival (22).”
Mechanisms of Vascular Aging (2018, positive): “of SIRT1 were shown to attenuate vascular inflammation in aged mice.(59,80)”
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function (2012, background): “Thismouse further corroborates the striking parallels between resveratrol treatment, CR, and increased SIRT1 activity (Baur et al., 2006; Cohen et al., 2004; Pearson et al., 2008; Smith et al., 2009).”
NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus (2015, background): “…most data agree that sirtuin activation in mammals delays the onset of agerelated degenerative processes (Herranz et al., 2010; Kanfi et al., 2012; Pearson et al., 2008; Satoh et al., 2013) and that defective sirtuin activity impairs some of themetabolic and physiological benefits triggered by CR…”
Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases (2012, positive): “In mice, long-term administration of resveratrol induced gene expression patterns that resembled those induced by CR and delayed aging-related deterioration, even though it did not extend life span (Pearson et al., 2008).”
The Mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance (2015, background): “Reduced insulin sensitivity becomes apparent around one year of age in C57BL/6 mice (Pearson et al., 2008).”
Calorie restriction-like effects of 30 days of Resveratrol (resVida™) supplementation on energy metabolism and metabolic profile in obese humans (2011, background): “These beneficial effects of resveratrol on metabolism are in concordance with several findings of resveratrol supplementation in animals (Baur et al., 2006; Cantó et al., 2009; Lagouge et al., 2006; Pearson et al., 2008; Sun et al., 2007).”
The genetics of ageing (2010, background): “In one careful study, the plant polyphenolic compound resveratrol, which affects many processes in a sirtuin-dependent manner and has been reported to activate sirtuins, extended the lifespan of mice fed a high-fat diet but not that of mice fed a normal die”