Calorie restriction-like effects of 30 days of Resveratrol (resVida™) supplementation on energy metabolism and metabolic profile in obese humans

By S. Timmers, E. Konings, L. Bilet, R. Houtkooper, T. van de Weijer, G. Goossens, J. Hoeks, Sophie E. van der Krieken, D. Ryu, S. Kersten and 7 more. Cell Metabolism, 2011

1,276 citations recorded by the source corpus.

Summary Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol in a randomized double-blind cross-over study for 30 days. Resveratrol significantly reduced sleeping- and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1α protein levels, increased citrate synthase activity without change in mitochondrial content, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Furthermore, resveratrol elevated intramyocellular lipid levels, and decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Systolic blood pressure dropped and HOMA index improved after resveratrol. In the postprandial state, adipose tissue lipolysis and plasma fatty acid and glycerol decreased. In conclusion, we demonstrate that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.

Subfields: Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/87ec47fbe7791b76e5ed69fbac343fb2d8a31311

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Geriatrics and Gerontology

1. Johan Auwerx
2. R. Houtkooper
3. W. Gu
4. N. Kon
5. E. Pirinen
6. D. Accili
7. C. Cantó
8. D. Sinclair

In Physiology

1. R. Houtkooper
2. Johan Auwerx
3. E. Pirinen
4. M. Rosenbaum
5. W. Gu
6. S. Farmer
7. Marina K. Holz
8. B. Spiegelman

Citations in the corpus

• Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ (2012, positive): “Moreover, activation of SIRT1 by resveratrol decreased PPARg acetylation in human subcutaneous adipose tissue (Figure 5K), in agreement with the insulin-sensitizing effects of resveratrol in humans (Timmers et al., 2011).”
• The therapeutic potential of resveratrol: a review of clinical trials (2017, background): “found that treatment of obese men with 150 mg/ day of resveratrol for 30 days resulted in improved cellular and systemic markers of metabolism, such as increased mitochondrial respiration in the muscle and decreased circulating glucose and triglycerides.(72) Poulsen et al.”
• Novel insights of dietary polyphenols and obesity. (2014, background): “Timmers, 2011 [124] Randomized, placebo-controlled, double-blinded crossover study.”
• Sirtuins as regulators of metabolism and healthspan (2012, background): “Resveratrol improves mitochondrial activity and metabolic control in humans as wel”