Promoting Health and Longevity through Diet: from Model Organisms to Humans
By Luigi Fontana, Linda Partridge. Cell, 2015
1,138 citations recorded by the source corpus.
Reduced food intake, avoiding malnutrition, can ameliorate aging and aging-associated diseases in invertebrate model organisms, rodents, primates and humans. Recent findings indicate that meal timing is crucial, with both intermittent fasting and adjusted diurnal rhythm of feeding improving health and function, in the absence of changes in overall intake. Lowered intake of particular nutrients, rather than of overall calories, is also key, with protein and specific amino acids playing prominent roles. Nutritional modulation of the microbiome can also be important, and there are long-term, including inter-generational, effects of diet. The metabolic, molecular and cellular mechanisms that mediate the responses of health during aging to diet, and genetic variation in response to diet, are being identified. These new findings are opening the way to specific dietary and pharmacological interventions to recapture the full potential benefits of dietary restriction, which humans can find hard to maintain voluntarily.
Subfields: Aging, Physiology
View Paper: https://www.semanticscholar.org/paper/5477677cee1d3662ca125d60cbe61f5555ac965f
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Aging
In Physiology
- L. Galluzzi
- Guido Kroemer
- C. López‐Otín
- Nir Barzilai
- Stephen B. Kritchevsky
- Mark A. Espeland
- J. Crandall
- V. Schirrmacher
Citations in the corpus
- Metformin as a Tool to Target Aging (2016, positive): “discussed and developed in recent reviews (de Cabo et al., 2014; Fontana and Partridge, 2015; Fontana et al., 2010).”
- Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018, neutral): “Both the quantity and quality of what we eat is essential to promote metabolic and molecular health (6).”
- Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota (2017, positive): “Recently, intermittent fasting was demonstrated to optimize energy metabolism and promote health (Fontana and Partridge, 2015; Longo and Mattson, 2014).”
- Metabolic Control of Longevity. (2016, background): “Accordingly, reduction of dietary amino acids—notably, tryptophan and methionine—can extend lifespan in animal models (Fontana and Partridge, 2015).”
- ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases (2016, background): “In parallel, all the suggested methods to prolong lifespan, as caloric restriction and increased activity of SIRT1, share the OS reduction effect [107].”