Directed actin polymerization is the driving force for epithelial cell-cell adhesion.

By V. Vasioukhin, C. Bauer, M. Yin, Elaine Fuchs. Cell, 2000

1,244 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f71e94b995f3e8471390fe2047cd7293ac3dd269

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Citations in the corpus

EMT, the cytoskeleton, and cancer cell invasion (2009, background): “CD151 appears to be important for the filopodia-based “adhesion zipper formation”, a process by which initial filopodia-mediated contacts of epithelial cells develop into mature cell-cell junctions [36, 37].”
Sticky business: orchestrating cellular signals at adherens junctions. (2003, positive): “However, members of the zyxin and Vasp/Ena family of proteins can be observed at puncta, which are can generate filopodia), Rac (which mediates lamellipodia formation), and Rho (which promote stress fiber also sites of active actin polymerization (Vasioukhin et al., 2000).”
Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. (2001, neutral): “The elegant studies of Vasioukhin et al. (2000) have given”
Collective cell migration in morphogenesis, regeneration and cancer (2009, background): “Actin-rich cell protrusions not only establish directionality and sense and attach to tissue structures at the cell front, they also cross-signal rearwards to and foster attachment of follower cells through E-cadheri”
Hyperproliferation and Defects in Epithelial Polarity upon Conditional Ablation of α-Catenin in Skin (2001, neutral): “, under condigrowth (Vasioukhin et al., 2000).”
The many faces of actin: matching assembly factors with cellular structures (2007, background): “On initial contact, the two interacting cells extend actin-rich finger-like protrusions toward each other, with cadherin concentrated at the tip”
Intercellular adhesion, signalling and the cytoskeleton (2002, background): “α-catenin can bind directly to actin filaments, or indirectly, through the linker protein vinculin, which in turn binds VAS”
Rho GTPases: biochemistry and biology. (2005, background): “Numerous reports indicate that adherens junction assembly is preceded by the localized induction of filopodia and/or lamellipodia and that these protrusive structures drive intimate membrane contact between adjacent cells (Ehrlich et al. 2002, Jacinto et al. 2000, Vasioukhin et al. 2000).”
Adherens junctions: from molecules to morphogenesis (2010, background): “In primary keratinocytes, filopodia mediate contact formation and this also leads to cadherin clustering at the ends of radial actin filament”
Getting under the skin of epidermal morphogenesis (2002, background): “Both of these intercellular junctions are essential for epithelial sheet formatio”
Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members. (2002, background): “Cadherins on one cell surface form a series of rigid dimers that present several of the cadherin repeats to equivalent dimers on the opposing cells (29); lateral motion of these complexes allows the cell junction site to zip up in order to form a stable adhesion (21, 30).”
A renaissance for SRC (2004, background): “α-catenin can bind to actin filaments either directly or indirectly, through intermediate molecules such as vinculin and VAS”