Rho GTPases: biochemistry and biology.

By A. Jaffe, Alan Hall. Annual Review of Cell and Developmental Biology, 2005

3,098 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/98f9550b50d0aede9d8b10651a5757b45a722ac6

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Citations in the corpus

A Landscape of Driver Mutations in Melanoma (2012, background): “Its best-characterized function is regulation of cytoskeleton rearrangement, and thus it plays important roles in cellular adhesion, migration, and invasion (Jaffe and Hall, 2005).”
Linking actin dynamics and gene transcription to drive cellular motile functions (2010, neutral): “The Rho GTPases encompass members of the Rho, Rac and Cdc42 subfamilie”
The Hippo pathway: regulators and regulations. (2013, result): “These results are consistent with a general role of Rho GTPases in regulating dynamics of the actin cytoskeleton and promoting cell proliferation (Jaffe and Hall 2005).”
Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression (2015, background): “specific effects to the actin cytoskeleton.(14,15) Of these, RhoA, -B, and -C comprise the Rho subgroup of Rho GTPases, which have redundant functions and from here on will be discussed simply with respect to findings regarding RhoA.”
Mammalian Rho GTPases: new insights into their functions from in vivo studies (2008, background): “In addition, they regulate vesicle transport, microtubule dynamics, cell-cycle progression and gene expressio”
Rho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity (2010, background): “Rho family small GTPases, such as Rho, Rac, and Cdc42, regulate cytoskeletal reorganization in different ways [Kaibuchi et al., 1999; Jaffe and Hall, 2005].”
Shaping cups into phagosomes and macropinosomes (2008, background): “These GTPases associate with membranes by regulated exposure of covalently associated acyl chains and by non-covalent interactions with phospholipids or membrane protein”
Manipulation of thyroid status and/or GH injection alters hepatic gene expression in the juvenile chicken (2007, background): “CDC42EP1 is a binding protein, which inactivates CDC42, a major GTPase that regulates cell polarity, motility and proliferation (Schmitz et al., 2000; Burridge and Wennerberg, 2004; Etienne-Manneville, 2004; Jaffe and Hall, 2005; Fidyk et al., 2006).”
Branching out: mechanisms of dendritic arborization (2010, background): “These small GTPases also influence the dynamics and plus-end capture of microtubule”
GTP‐binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo (2007, background): “All these pathways have been extensively reviewed before and will not be re-mentioned here.(2,5) However, it should be noted that the activation of effectors might fire back on the GTPases themselves, thus contributing to the generation of balanced and time-restricted signals by Rho/Rac proteins.”