A renaissance for SRC

By Timothy Yeatman. Nature Reviews. Cancer, 2004

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The Blood-Testis Barrier and Its Implications for Male Contraception (2012, background): “Of these, c-Src is the best studied Src kinase family member, and since being discovered y by Francis Peyton Rous in 1911, it has been implicated in oncogenesis (Martin, 2001, 2009; Yeatman, 2004; Aleshin and Finn, 2010) (Fig.”
The LIR motif – crucial for selective autophagy (2013, background): “Increased Src activity promotes tumorigenesis but excessive Src signaling can be cytotoxic (Yeatman, 2004).”
Small molecule-induced DNA damage identifies alternative DNA structures in human genes (2012, positive): “SRC is a nonreceptor tyrosine kinase that has crucial roles in various cellular processes, including cell motility and invasio”
Src kinases as therapeutic targets for cancer (2009, background): “The nine members of the Src-family kinases (SFKs) are c-Src, Yes, Fyn, Lyn, Lck, Hck, Fgr, Blk, and Yrk”