Adherens junctions: from molecules to morphogenesis

By T. Harris, U. Tepass. Nature reviews. Molecular cell biology, 2010

965 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components (2011, background): “Cadherins mediate Ca-dependent cell adhesion and cell junction formation, and their cytoplasmic domains are associated with various catenins that mediate cytoskeletal association and signaling (6).”
Structural and functional diversity of cadherin at the adherens junction (2011, background): “In both vertebrates and Drosophila, cad herins are required not only for static cell–cell contacts but also for regulation of dynamic morphogenetic processes (Nishimura and Takeichi, 2009; Harris and Tepass, 2010).”
Circulating Tumor Cell Clusters are Oligoclonal Precursors of Breast Cancer Metastasis (2014, background): “…contributes to both adherens junctions and desmosomes: in adherens junctions, the C-terminal intracellular domain of E-cadherin interacts in a mutually exclusive manner with either b-catenin or plakoglobin, which in turn associates with the actin-binding protein a-catenin (Harris and Tepass, 2010).”
Cancer invasion and the microenvironment: plasticity and reciprocity. (2011, positive): “In both stable and dynamic cell-cell adhesion, cadherins engage with cytoskeletal adaptor and signaling proteins, including a-catenin, b-catenin, and p120-catenin, which connect to the actin and microtubule cytoskeleton (Berx and van Roy, 2009; Harris and Tepass, 2010; Reynolds, 2010).”