Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis.

By Jing Yang, Sendurai A Mani, Joana Liu Donaher, Sridhar Ramaswamy, R. Itzykson, C. Côme, P. Savagner, I. Gitelman, A. Richardson, R. Weinberg. Cell, 2004

3,963 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/f5894987729c871fefe1c4c99cdd1f3490340344

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. R. Weinberg
2. M. Nieto
3. Thomas Brabletz
4. Jing Yang
5. Rakesh K. Jain
6. J. Massagué
7. D. Hanahan
8. Raghu Kalluri

In Oncology

1. R. Weinberg
2. M. Nieto
3. Thomas Brabletz
4. J. Massagué
5. Jing Yang
6. D. Hanahan
7. Rakesh K. Jain
8. E. Hay

Citations in the corpus

• E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer (2009, background): “members of the zinc finger homeobox (ZFH) family of repressors, ZEB1 and ZEB2 [3–14].”
• The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis (2022, background): “Moreover, TWIST overexpression is associated with tumor invasion and metastasis [84, 85].”
• Epithelial–mesenchymal transition in development and cancer: role of phosphatidylinositol 3′ kinase/AKT pathways (2005, background): “Recent studies have confirmed this hypothesis by showing that the basic helix–loop–helix transcription factor Twist plays a critical role in the early steps of metastasis (Yang et al., 2004).”
• Involvement of members of the cadherin superfamily in cancer. (2009, background): “Twist, another EMTregulating transcription factor, is involved in breast tumor metastasis (Yang et al. 2004), and its expression rises as nodal involvement increases (Martin et al. 2005).”
• TGF-β and epithelial-to-mesenchymal transitions (2005, background): “Twist has been recently identified as a important regulator of EMT in vitro and in vivo in metastatic and invasive carcinomas (Yang et al., 2004).”
• NF-κB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2 (2007, background): “In the 4T1 model system, the Twist gene has been shown to mediate EMT (Yang et al., 2004).”
• Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics. (2009, background): “EMT is characterized by the up-regulation of vimentin and of Ecadherin repressor molecules (snail/slug/twist) with down-regulation of E-cadherin and other cell adhesion molecules (45, 48, 49).”
• The transcriptional repressor Snail promotes mammary tumor recurrence. (2005, background): “A subset of human breast cancers and human breast cancer cell lines display features of EMT (Hajra et al., 2002; Yang et al., 2004); in addition, suppression of CK8 and expression of vimentin have each been correlated with decreased survival of breast cancer patients (Fuchs et al.”
• Metastasis: a question of life or death (2006, background): “, was recently shown to be involved in breast cancer metastasis through the regulation of EM”
• Genetic determinants of cancer metastasis (2007, background): “In a lobular breast cancer model, overexpression of twist and snail, master transcriptional regulators of morphogenesis, promotes EMT and intravasatio”
• Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. (2012, background): “In mouse and human breast tumor xenograft models, Twist1 expression can promote tumor metastasis (Yang et al., 2004).”