Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis.
By J. Tsai, Joana Liu Donaher, D. Murphy, S. Chau, Jing Yang. Cancer Cell, 2012
1,096 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/26fbcf536230be55dbe2be1aab6ea6c7418c6fa3
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Genetics
- R. Weinberg
- M. Nieto
- Thomas Brabletz
- Jing Yang
- J. P. Thiery
- Raghu Kalluri
- D. Pattabiraman
- Arthur W. Lambert
In Molecular Biology
- R. Weinberg
- M. Nieto
- Raghu Kalluri
- Jing Yang
- Thomas Brabletz
- J. P. Thiery
- Simone Brabletz
- D. Pattabiraman
In Oncology
- R. Weinberg
- M. Nieto
- Thomas Brabletz
- Raghu Kalluri
- Jing Yang
- J. P. Thiery
- Simone Brabletz
- D. Pattabiraman
Citations in the corpus
- Dynamic EMT: a multi‐tool for tumor progression (2021, positive): “In 2012, Tsai et al (2012) demonstrated that EMT induction, in this case via TWIST, supports tumor cell dissemination in a mouse model of skin cancer, but subsequent Twist1 downregulation and MET was necessary for colonization and formation of macrometastases (Tsai et al , 2012) (Fig 3).”
- Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients (2014, positive): “(Thiery, 2002); in agreement was the recent demonstration that reversing EMT may promote metastatic colonization (Tsai et al , 2012).”
- EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, positive): “Indeed, such reversals by many cells within an early metastatic growth to a more epithelial state may actually be essential for metastatic colonization (Del Pozo Martin et al., 2015; Korpal et al., 2011; Ocana et al., 2012; Tsai et al., 2012).”
- Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells (2013, methodology): “used this model to show that Twist needs to be downregulated for metastasis to occur (60).”
- Targeting Epithelial–Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer (2016, background): “Down-regulation of Twist1, in turn, reversibly redifferentiate the EMT cells into epithelial cell type at the site of metastasis where the cells start colonizing and proliferating [121].”
- Epithelial–mesenchymal transition in tumor metastasis (2016, methodology): “As discussed above, the EMT plasticity in metastasis was indeed reflected in CTCs both in mouse tumor models and in human patients (Celi a-Terrassa et al., 2012; Tsai et al., 2012).”
- The Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? (2015, neutral): “TGF-b causes EMT before extravasation, but MET after extravasation, by a yet-unknown mechanism.”