Genetic determinants of cancer metastasis

By D. Nguyen, J. Massagué. Nature reviews genetics, 2007

809 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/f18d93f091e90b43e451d3a3eaff6efe9e65ab7c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. J. Pollard
2. J. Joyce
3. Y. Fouad
4. C. Aanei
5. George A. Calin
6. J. Massagué
7. M. Shimizu
8. Simona Rossi

In Molecular Biology

1. J. Joyce
2. J. Pollard
3. Y. Fouad
4. C. Aanei
5. J. Massagué
6. D. Nguyen
7. George A. Calin
8. Binzhi Qian

In Oncology

1. J. Pollard
2. J. Joyce
3. J. Massagué
4. Y. Fouad
5. C. Aanei
6. R. Weinberg
7. D. Nguyen
8. Binzhi Qian

Citations in the corpus

• Metastasis: from dissemination to organ-specific colonization (2009, background): “General classes of metastasis genes The genes and activities that underlie these general steps of metastasis can be grouped into several classes, which we define as metastasis initiation, metastasis progression and metastasis virulence gene”
• A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth (2009, background): “Recently, many changes in the tumor cell have been identified that allow them to become metastatic and to have a particular trophism to a tissue such as bone or liver [7].”
• MicroRNAs — the micro steering wheel of tumour metastases (2009, background): “However, the molecular pathways underlying each step are still obscur”
• Exosomes in Cancer Development, Metastasis and Drug Resistance: A Comprehensive Review (2013, neutral): “Researchers are still grappling to understand the underlying drivers of migratory cells and their ability to escape the site of origin in primary tumors [152].”
• Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling. (2010, neutral): “– TGFb signaling (Oft et al. 1996; MercadoPimentel and Runyan 2007; Nguyen and Massague 2007).”
• Microenvironmental regulation of metastasis (2009, methodology): “More recent versions of these experiments have used the power of transcriptome profiling to identify cohorts of genes of which expression confers both enhanced metastatic potential and altered tissue tropis”
• Revisiting the hallmarks of cancer. (2017, positive): “A cooperation between genes mediating organ-specific metastasis [132] and adaptive programs working in the receptive tissue [129, 133] seem to be at play.”
• Overexpression of Long Non-coding RNA HOTAIR Predicts Tumor Recurrence in Hepatocellular Carcinoma Patients Following Liver Transplantation (2011, background): “Metastasis is a complicated process, involving multiple steps and a variety of genes.(16,17) It is becoming evident that a large proportion of long noncoding RNAs that are pervasively transcribed in the genome are highly conserved and, thus, biologically functional, yet their potential role in human”