Metastasis: a question of life or death

By P. Mehlen, A. Puisieux. Nature Reviews. Cancer, 2006

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How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Integrative Clinical Genomics of Metastatic Cancer (2017, neutral): “In over 90% of cases, metastatic spread of tumor cells is the greatest contributor to deaths from cancer 1,2 .”
In Vitro Tumor Models: Advantages, Disadvantages, Variables, and Selecting the Right Platform (2016, background): “Metastasis is responsible for more than 90% of cancer-related deaths (Weigelt et al., 2005; Mehlen and Puisieux, 2006); however, many details of the steps in the metastatic cascade remain poorly understood (Wirtz et al., 2011).”
Microenvironmental regulation of metastasis (2009, background): “Each of these stages is inefficient and some are rate limitin”
The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. (2013, background): “Metastasis is the major cause of cancer recurrence and tumor-related death (2, 3).”
Cancer metastasis: building a framework. (2006, background): “Ectopic overexpression of potent anti-apoptotic effectors, such as BCL2, BCL-XL, and XIAP, in cancer cells can make them highly resistant to death stimuli, which has been shown to enhance the efficiency of metastasis in numerous experimental models (Mehlen and Puisieux, 2006).”