The transcriptional repressor Snail promotes mammary tumor recurrence.

By S. Moody, D. Perez, Tien-Chi Pan, Christopher J. Sarkisian, C. P. Portocarrero, Christopher J Sterner, Kathleen L Notorfrancesco, R. Cardiff, L. Chodosh. Cancer Cell, 2005

763 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/002fe46a688bf95a086a415278e9bff1496107b5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. M. Nieto
2. Lisa M. Coussens
3. J. P. Thiery
4. R. Weinberg
5. B. Ruffell
6. R. Huang
7. V. Raman
8. N. Ramirez

In Molecular Biology

1. M. Nieto
2. R. Weinberg
3. Jing Yang
4. J. P. Thiery
5. X. Ye
6. K. Yeung
7. R. Huang
8. Erik W. Thompson

In Oncology

1. M. Nieto
2. R. Weinberg
3. Jing Yang
4. J. P. Thiery
5. Lisa M. Coussens
6. X. Ye
7. R. Huang
8. K. Yeung

Citations in the corpus

• EMT and dissemination precede pancreatic tumor formation (2012, background): “Although several studies support a physiologic role during tumor progression (Moody et al., 2005; Trimboli et al., 2008), most studies of EMT in the context of cancer biology have been conducted in vitro, and thus the relevance of EMT to carcinogenesis continues to be debated (Ledford, 2011).”
• The epithelial–mesenchymal transition: new insights in signaling, development, and disease (2006, neutral): “For example, expression of Snail1 increases the aggressiveness of experimentally induced breast tumors, and high Snail1 expression correlates with an increased risk of tumor relapse and poor survival rates in human breast cancer (Moody et al., 2005).”
• CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. (2011, methodology): “These recurrent tumors are HER2/Neu independent, show upregulated expression of Snail, and acquire mesenchymal characteristics in a manner resembling EMT (1).”
• The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 (2008, background): “Several studies using in vivo mouse-model systems have suggested that EMT is involved in breast cancer metastasi”
• Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression (2010, background): “In infiltrating ductal carcinoma, Snail expression correlates with lymph node metastasis and with decreased relapse free survival [115, 116], while Slug correlates with metastasis [117].”
• The Role of Snail in EMT and Tumorigenesis (2013, background): “Expression of Snail positively correlates with tumor grade, recurrence, metastasis, and poor prognosis in various tumors [5-8].”
• Involvement of members of the cadherin superfamily in cancer. (2009, background): “A new role for Snail in tumor recurrence has been inferred from a reversible HER-2/neu-induced breast cancer mouse model (Moody et al. 2005).”
• NF-κB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2 (2007, background): “Furthermore, there is recent evidence for the role of EMT in tumor recurrence after therapy (Moody et al., 2005).”
• Epithelial—mesenchymal and mesenchymal—epithelial transitions in carcinoma progression (2007, background): “Importantly, Snail1 was central to the signature found associated with recurrence in a mouse mammary tumor model, suggesting an important role in the survival of minimal residual disease (Moody et al., 2005).”
• Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy (2011, methodology): “Both datasets were examined on the same array platform (Affymetrix U133A), using a standard operating procedure and normalization method (dCHIP) as previously reported (57, 58).”
• Epithelial-mesenchymal transitions in development and disease. (2009, background): “Snail1 expression is correlated with breast tumor recurrence (Moody et al., 2005), and Snail is associated with the activation of immunosuppressive cytokines, regulatory T cells, cytotoxic T lymphocytes resistance, and the generation of impaired den-”
• The epidermal growth factor receptor family: Biology driving targeted therapeutics (2008, background): “Up-regulation of the transcriptional repressor Snail promoted this neu-independent mammary tumor recurrence [152].”
• Epithelial–mesenchymal transition in tumor metastasis (2016, background): “In addition, SNAIL1 overexpression in primary Neu-driven mammary tumor grafts led to an increased rate of tumor recurrence, after transplantation into nude mice (Moody et al., 2005).”
• Direct regulation of TWIST by HIF-1α promotes metastasis (2008, background): “Overexpression of Snail induces invasion and metastasis of different types of human cancer”