NF-κB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2

By H. Chua, P. Bhat-Nakshatri, S. Clare, A. Morimiya, S. Badve, Harikrishna Nakshatri. Oncogene, 2007

625 citations recorded by the source corpus.

Subfields: Cancer Research, Oncology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/dc3877a908aeb8da630bea671dc88c583fef08ea

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Thomas Brabletz
2. M. Nieto
3. J. López-Novoa
4. C. Bracken
5. Gautam Sethi
6. Gregory J. Goodall
7. E. Lengyel
8. Marcus E. Peter

In Oncology

1. M. Nieto
2. Thomas Brabletz
3. J. López-Novoa
4. E. Lengyel
5. H. Beug
6. W. Mikulits
7. R. Weinberg
8. Jing Yang

In Pulmonary and Respiratory Medicine

1. M. Nieto
2. Thomas Brabletz
3. E. Lengyel

Citations in the corpus

• The transcription factor ZEB1 (δEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity (2007, background): “Candidates for ZEB1 inducers are TGFb, tumour necrosis factor-a (TNF-a) and Wnts, which are often excessively produced by different tumour-associated stroma cells (Ohira et al., 2003; Chua et al., 2006; Nishimura et al., 2006).”
• Inflammation and EMT: an alliance towards organ fibrosis and cancer progression (2009, background): “NF-kB can also directly activate the expression of potent EMT inducers, including Snail1 and Zeb factors (Bachelder et al, 2005; Barberà et al, 2004; Chua et al, 2007; Julien et al, 2007; Kim et al, 2007) (Fig 3).”
• A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. (2008, background): “Similar phenotypic effects of ZEB1 or SIP1 manipulation have also been observed in a range of human cancer cell lines resulting in a change in their invasive capacity (15, 16, 27, 28).”
• The Role of Resveratrol in Cancer Therapy (2017, background): “The roles for NF-κB have been found to be linked to the expression of various genes related to EMT, such as ZEB1, Snail, E-cadherin, MMP-7, MMP-9, and MMP-13 [192,193,195,196].”
• The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. (2008, background): “…1 [SIP1])—are important regulators in the complex network of transcriptional repressors that regulate the expression of E-cadherin and EMT through repression of a number of master regulators of epithelial polarity (Comijn et al. 2001; Eger et al. 2005; Aigner et al. 2007; Shirakihara et al. 2007).”