Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection.

By S. Kaech, E. Wherry. Immunity, 2007

682 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f52a4107de375311d6356ac4691e2c633f4c2c3f

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In Immunology

Citations in the corpus

NK cell development, homeostasis and function: parallels with CD8+ T cells (2011, background): “The overall memory CD8 + T cell compartment has been described to contain at least two subsets: central and effector memory T cell population”
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells (2009, background): “Antigen-experienced memory T cells can be distinguished from T N cells not only by phenotype but also by a number of functional properties, including rapid acquisition of effector functions upon antigen rechalleng”
Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity (2012, background): “CD8 + T cells have a pivotal role in antiviral immunity in target tissue”
Differentiation and persistence of memory CD8+ T cells depend on T cell factor 1 (2010, background): “The transition of effector to memory CD8+ T cells is affected by extracellular stimuli including the strength and timing of stimulatory signals derived from T cell receptor (TCR)antigen interactions, costimulation, and inflammatory cytokines including interferons and IL-12 (Harty and Badovinac, 2008”
Human T cell development, localization, and function throughout life (2018, background): “…clearance; contraction, in which the majority of effector T cells die by apoptosis following infection; and a memory phase, in which a fraction of these primed T cells persist as long term memory T cells that protect against subsequent infection (Gourley et al., 2004; Kaech and Wherry, 2007).”
Inflammatory Cytokines as a Third Signal for T Cell Activation (2010, neutral): “The percent of activated cells that survive long-term as memory cells is decreased when the effector pool has a high proportion of SLEC, but the absolute size of the memory pool may be relatively unaffected.”
Redefining chronic viral infection. (2009, positive): “Memory CD8 and CD4 T cell differentiation following acute viral infections results in the formation of highquality, long-lived memory cells (Kaech and Wherry, 2007).”
Blimp-1 promotes terminal differentiation of virus-specific CD8 T cells and represses the acquisition of central memory T cell properties (2009, background): “Memory T cells are a major component of long-term immunity because of their longevity and other unique properties that include the ability to maintain a high proliferative potential in order to expand robustly upon secondary infection, rapidly reexpress cytotoxic proteins and cytokines upon restimul”
Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity (2010, positive): “After contraction, T effector memory (Tem) (IL-7Rahi, CCR7lo, CD62Llo, KLRG-1lo, IL-2lo) and T central memory (Tcm) (IL-7Rahi, CCR7hi, CD62Lhi, KLRG-1neg/lo, IL-2hi) cells are found (Kaech and Wherry, 2007).”
The mTOR kinase determines effector versus memory cell fate of CD8+ T cells by regulating T-bet and Eomesodermin expression (2010, background): “Instructions received by a naive CD8+ T cell imprint differentiation into short-lived effectors and/or long-lived memory fates by regulating gene programs governed by master transcriptional factors (Kaech and Wherry, 2007).”
From Vaccines to Memory and Back (2010, positive): “In mice the precursors of memory CD8 T cells could be identified as IL-7R hi cells, while the more abundant KLRG1 hi cells were shown to represent short lived effector cells (Joshi et al., 2007; Kaech et al., 2003; Kaech and Wherry, 2007; Sarkar et al., 2008).”
Coregulation of CD8+ T cell exhaustion during chronic viral infection by multiple inhibitory receptors (2008, background): “1679" language="eng" relation="no"> After acute viral infection, memory CD8 + T cells rapidly reactivate effector functions, have high proliferative potential and are maintained by antigen-independent homeostatic proliferatio”
Antigen independent differentiation and maintenance of effector-like resident memory T cells in tissues (2012, background): “In contrast, persistent infections that result in repetitive Ag exposure result in recirculating TEM that may be maintained indefinitely at the population level, although maintenance may be dependent upon Ag persistence (10, 12).”