Role of nrf2 in oxidative stress and toxicity.

By Q. Ma. Annual Review of Pharmacology and Toxicology, 2013

4,437 citations recorded by the source corpus.

Subfields: Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/665a25f50e575cfb0bb06b2942b9263d021faf24

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Citations in the corpus

Activation of the p62-Keap1-NRF2 Pathway Protects against Ferroptosis in Hepatocellular Carcinoma Cells (2015, background): “The nuclear factor erythroid 2-related factor 2 (NRF2) is a key regulator of the antioxidant response.(5)”
Defatted Biomass of the Microalga, Desmodesmus sp., Can Replace Fishmeal in the Feeds for Atlantic salmon (2016, background): “GSTA2 (glutathione S-transferase A2) and NQO1 (NADPH: quinone oxidoreductase 1) are two Nrf2-regulated genes (Ma, 2013), and gstp1 and nqo1 were altered in zebrafish exposed to toxins (Lam et al., 2008).”
Metallothionein-1G Facilitates Sorafenib Resistance through Inhibition of Ferroptosis (2016, background): “NRF2 is a basic leucine zipper transcription factor that regulates redox balance and the stress response triggered by injury and inflammation.((33)) Under unstressed conditions, Kelch-like ECH-associated protein 1 constitutively ubiquitinates NRF2, resulting in the rapid degradation of NRF2 through ”
Reactive oxygen species and mitochondria: A nexus of cellular homeostasis (2015, neutral): “disrupting the Keap1–Nrf2 interaction [160].”
Hyperglycemia and Oxidative Stress: An Integral, Updated and Critical Overview of Their Metabolic Interconnections (2023, background): “For instance, some PKC isoforms show two different domains with Cys-rich motifs [66] that can be involved in cysteine thiol-based redox signaling that regulates Nrf2 and thioredoxin active forms (Sections 5 and 5.”
Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives (2015, positive): “Growing evidence has demonstrated that the Nrf2 antioxidant response pathway plays an important role in the cellular antioxidant defense by activating a wide variety of genes involved in early defence reactions of higher organisms [158,159].”
The Tumor Suppressor Protein p53 and the Ferroptosis Network (2018, positive): “NFE2L2/NRF2 (nuclear factor, erythroid 2 like 2) is a master transcription factor that controls the cellular response to oxidative or electrophilic stresses [45].”
NRF2 and the Hallmarks of Cancer. (2018, background): “This cancer-preventive side of NRF2 has been extensively reviewed elsewhere (Kensler et al., 2007, Ma, 2013, Jaramillo and Zhang, 2013, Harder et al., 2015).”