Adult cardiac stem cells are multipotent and support myocardial regeneration.

By A. Beltrami, Laura Barlucchi, D. Torella, M. Baker, Federica Limana, S. Chimenti, H. Kasahara, M. Rota, E. Musso, K. Urbanek and 4 more. Cell, 2003

3,740 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/ef642c7fbbd63df88a0466df32eb4b1385f39f36

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In Genetics

1. A. Caplan
2. J. Karp
3. Yibin Kang
4. J. Massagué
5. Deepak Srivastava
6. D. Prockop

In Molecular Biology

1. Stefanie Dimmeler
2. A. Zeiher
3. C. Urbich
4. B. Bruneau
5. J. Massagué
6. O. Bergmann
7. Yibin Kang
8. J. Frisén

In Surgery

1. A. Caplan
2. J. Karp

Citations in the corpus

• Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury (2007, background): “To exclude the possibility that cardiac stem cells were labeled with GFP, we performed immunostaining for the stem-cell markers Kit and Sca-1 (also known as Ly6a) together with GF”
• A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. (2006, neutral): “EGFP folds and fluoresces more rapidly than DsRed2 ( Baird et al., 2000; Bevis and Glick, 2002)—approximately one day faster in embryonic zebrafish CMs activating the cmlc2 promoter for the first time (Figure S1).”
• Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease (2012, background): “, 2010), evidence suggests that CSCs possess only a limited capacity to differentiate into fully mature cardiomyocytes with an adult phenotype (Beltrami et al., 2003; Urbanek et al., 2005).”
• Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors (2010, background): “We found that any potential rare cardiac “progenitor-like” cells, marked by c-kit or Isl1, were dispensable for cardiomyocyte induction (Beltrami et al., 2003).”
• Mesenchymal stem cells as trophic mediators (2006, background): “Additional complexities arise in light of recent evidence that cardiac tissue may itself contain stem cells [Beltrami et al., 2003] which could be the targets of ischemia-induced signaling, such as SDF-1, or are the targets of MSCFig.”
• Beyond tumorigenesis: cancer stem cells in metastasis (2007, background): “In addition to the well-characterized HSCs, adult stem cells have also been found in a variety of tissues and organs including muscle, intestine, brain, skin/hair follicles, heart, lung and, more recently, mammary glands [ 4-8 ].”
• Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction (2015, background): “, Steven R Houser, PhD.(3,4), Walter J Koch, PhD.”
• Dynamics of Cell Generation and Turnover in the Human Heart. (2015, result): “Moreover, we could not find any differences inmyocyte renewal comparing the apex with the heart basis, as one might have expected from studies reporting a higher frequency of stem cell niches in the apical regions in which the hemodynamic workload is lower (Beltrami et al., 2003).”
• Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages (2005, methodology): “Various cell surface markers have been used to purify precursor cells from heart muscle including c-kit and sca-1 (ref”