Dynamics of Cell Generation and Turnover in the Human Heart.
By O. Bergmann, Sofia Zdunek, Anastasia Felker, M. Salehpour, K. Alkass, Samuel Bernard, Staffan L. Sjostrom, M. Szewczykowska, T. Jackowska, C. dos Remedios and 8 more. Cell, 2015
1,046 citations recorded by the source corpus.
The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived (14)C revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (<4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to <1% per year in adulthood, with similar turnover rates in the major subdivisions of the myocardium. We provide an integrated model of cell generation and turnover in the human heart.
Subfields: Molecular Biology, Surgery
View Paper: https://www.semanticscholar.org/paper/25a24f92174437baaa95ec2c07a7211461347257
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Surgery
Citations in the corpus
- Revisiting Cardiac Cellular Composition (2015, background): “This is because of the variability and dynamism of the number of nuclei per cardiomyocyte in addition to the differences between rodents and humans—most murine cardiomyocytes are binucleated,(32,33) whereas most human cardiomyocytes are mononucleated.(2,34) Therefore, estimations of myocyte to nonmy”