Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury

By P. Hsieh, V. Segers, Michael E. Davis, Catherine Macgillivray, Joseph Gannon, J. Molkentin, J. Robbins, Richard T. Lee. Nature Medicine, 2007

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Stem-cell therapy for cardiac disease (2008, background): “, but this probably occurs at a very low rate in the absence of injur”
Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation (2010, background): “(3) One sample from the posterior noninfarcted left ventricular (LV) wall.”
Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells (2008, background): “Whether a specific cell population is derived from another cell type or it is maintained through self-duplication can be established by analyzing the genetic labeling frequency at different time points after induction of recombination [29,30].”
Dynamics of Cell Generation and Turnover in the Human Heart. (2015, background): “…both the origin of new cardiomyocytes (Bersell 1566 Cell 161, 1566–1575, June 18, 2015 ª2015 Elsevier Inc. et al., 2009; Ellison et al., 2013; Hsieh et al., 2007; Senyo et al., 2013; Uchida et al., 2013; van Berlo et al., 2014) and the extent of cell generation (Bergmann et al., 2009;…”
Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. (2009, neutral): “Results are means ± SEM of at least seven animals per experiment. the a-MHC promoter-dependent genetic label (Hsieh et al., 2007).”