Beyond tumorigenesis: cancer stem cells in metastasis
By Feng Li, Benjamin Tiede, J. Massagué, Yibin Kang. Cell Research, 2007
644 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/f34b3a2d96e51a9fdaa3f82a02d493b353fcbfe5
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cell Biology
In Molecular Biology
In Oncology
- R. Weinberg
- Yibin Kang
- Charlotte Kuperwasser
- J. Talmadge
- Eric S. Lander
- M. Wicha
- I. J. Fidler
- G. Dontu
Citations in the corpus
- Identification of selective inhibitors of cancer stem cells by high-throughput screening (2009, background): “CSCs have been proposed to be responsible for colonization at secondary organ sites upon metastatic dissemination (Li et al., 2007b; Croker and Allan, 2008).”
- AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective (2010, positive): “This theory has developed into the CSC hypothesis, which states that cancers develop from a subset of malignant cells that possess stem cell characteristics, such that tumors have rare cells with infinite growth potential (190).”
- Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy (2008, background): “Moreover, single cell clones derived from the same cancer cell line are not equally tumorigenic or metastatic [34-36].”
- Hypoxia and hypoxia-inducible factors (HIFs): master regulators of metastasis (2010, background): “By definition, metastasis should originate from CSCs with tumor-initiating capabilities that allowDTCs to reconstitute growing, heterogeneous secondary tumors (46).”
- Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature (2009, positive): “It has been proposed that CSCs play a crucial role in cancer metastasis (26, 27).”
- Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes (2011, background): “These cells are thought to be important for initiation of metastases at distant site”