Mesenchymal stem cells as trophic mediators

By A. Caplan, J. Dennis. Journal of Cellular Biochemistry, 2006

2,977 citations recorded by the source corpus.

Subfields: Biomaterials, Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/83cd7a45a11a3adffde7558950d689b93879d8c5

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Citations in the corpus

Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation (2007, neutral): “These areas concern the regulation of other cell types by MSCs, including MSCs as trophic mediators [28] and the immunomodulatory effects of MSCs [29].”
Mesenchymal Stem Cells: Mechanisms of Immunomodulation and Homing (2010, background): “As such, numerous researchers have begun to regard MSC, not only as traditional differentiating stem cells, but also as cellular drug delivery vehicles [ 11, 12 ] .”
Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury. (2011, background): “Based on this observation and on findings indicating that tubular repopulation after AKI depends on the reentry into cycle of renal tubular cells survived to injury [42,43], it has been suggested that MSCs may provide a paracrine support to kidney repair [41].”
Why are MSCs therapeutic? New data: new insight (2009, background): “I interpret all of these models to have a common trophic mode of action of the MSCs: the MSCs secrete bioactive molecules that: (a) inhibit apoptosis and limit the field of damage or injury; (b) inhibit fibrosis or scarring at sites of injury; (c) stimulate angiogenesis and bring in a new blood supp”
Mechanisms of mesenchymal stem/stromal cell function (2016, background): “Despite several decades of research and progress, the specific paracrine mechanisms by which administered MSCs improve cell survival and self-renewal under particular contexts of tissue rescue/repair remain largely undefined [75, 77].”
Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine (2018, background): “In recent years, however, focus on the therapeutic effects of MSCs in regenerative medicine has been shifting to their activity through paracrine secretion instead of engraftment and differentiation into functional cells [2, 4].”
The potential of neural stem cells to repair stroke-induced brain damage (2009, neutral): “The application of MSCs in neural-degenerative diseases has been reviewed by others [ 11 , 14].”
The knee meniscus: structure-function, pathophysiology, current repair techniques, and prospects for regeneration (2011, background): “Second, MSCs secrete a large variety of immunoregulatory molecules, and contribute to the healing process of injured tissue by providing paracrine trophic mediators [118].”
Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties (2010, background): “The potential paracrine effects of the cells was suggested by the observations that the cells in culture secrete a large number of cytokines (9, 10).”
Mechanisms involved in the therapeutic properties of mesenchymal stem cells. (2009, background): “Recently, the concept of MSCs discussed above has been broadened to include the secretion of biologically active molecules that exert beneficial effects on other cells [44].”
Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium. (2008, background): “Recent reports suggest that some of the therapeutic effects of MSCs are mediated by paracrine factors secreted by these cells (Caplan and Dennis, 2006; Gnecchi et al., 2005; Gnecchi et al., 2006).”
Drug Delivery Systems and Materials for Wound Healing Applications (2018, positive): “In this case, the cells either populate and close the wound or serve as factories for production of biological factors regulating the wound environment [86].”
Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery. (2013, background): “To reconcile this discrepancy between the therapeutic efficacy of MSCs and the lack of MSC engraftment or differentiation at the site of injury, itwas proposed thatMSCs exert their therapeutic effects through secreted trophicmediators [99].”