Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease
By Sudhir H. Ranganath, O. Levy, M. Inamdar, J. Karp. Cell Stem Cell, 2012
799 citations recorded by the source corpus.
The broad repertoire of secreted trophic and immunomodulatory cytokines produced by mesenchymal stem cells (MSCs), generally referred to as the MSC secretome, has considerable potential for the treatment of cardiovascular disease. However, harnessing this MSC secretome towards meaningful therapeutic outcomes is challenging due to limited control on cytokine production following transplantation. This review outlines current understanding of the MSC secretome as a therapeutic for treatment of ischemic heart disease. We discuss ongoing investigative directions aimed at improving cellular activity and characterizing the secretome and its regulation in greater detail. Finally, we provide insights and perspectives for future development of the MSC secretome as a therapeutic tool.
Subfields: Biomaterials, Genetics, Surgery
View Paper: https://www.semanticscholar.org/paper/b1b42dc86f055a68544834fbceb50d12532d800c
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Citations in the corpus
- Mesenchymal stromal cells: sensors and switchers of inflammation. (2013, neutral): “Novel molecular tools aimed at defining the MSC secretome, proteome, and transcriptome are being employed to more precisely define the soluble factors that mediate MSC function (Ranganath et al., 2012).”
- Mesenchymal stromal cells: new directions. (2012, background): “Investigating MSCs as cytokine ‘‘factories’’ will likely uncover new mechanisms and identify compounds that may in some cases supplant the cells themselves (Ranganath et al., 2012).”
- Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization (2019, background): “Recent studies have demonstrated that interaction between MSCs and the inflammatory niche may largely rely on cell–cell communication through secretion of immunomodulatory secretomes.(35,36) Aside from numerous growth factors and cytokines produced by MSCs, exosomes have gained interest as intriguin”