A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration.

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Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration (2011, background): “Indeed, inhibition of FGF or PDGF signalling leads to incomplete regeneration and the formation of scar tissu”
Epithelial-mesenchymal transitions in development and disease. (2009, background): “A subpopulation of the tbx18-positive activated epicardial-derived cells must undergo an Fgf17b/Fgfr2, Fgfr4dependent EMT, required to invade the regenerating myocardium and facilitate coronary neovascularization (Lepilina et al., 2006).”
Zebrafish as a model to study cardiac development and human cardiac disease (2011, background): “The developmentally activated epicardial cells then invade the newly formed myocardium at the site of injury and create a dense vascular network that is likely to encourage regeneration.(59,60)”
Retinoic acid in development: towards an integrated view (2008, background): “The loss of tissue regenerative capacity in adult vertebrates could involve loss of expression of components of the retinoid pathway that induce Fgf expressio”