IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells.

By S. Pflanz, J. Timans, J. Cheung, R. Rosales, H. Kanzler, J. Gilbert, L. Hibbert, T. Churakova, M. Travis, E. Vaisberg and 11 more. 2002

1,563 citations recorded by the source corpus.

Subfields: Immunology

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In Immunology

1. D. Cua
2. V. Kuchroo
3. C. Weaver
4. Christopher A. Hunter
5. J. O’Shea
6. L. Harrington
7. Paul R. Mangan
8. M. Oukka

Citations in the corpus

• The biology of IL-12: coordinating innate and adaptive immune responses. (2003, background): “IL-27 binds to the previously identified orphan receptor WSX-1/TCCR, another receptor with homology to the gp130 family [84,87,88].”
• TH-17 cells in the circle of immunity and autoimmunity (2007, background): “It sends signals through a receptor complex composed of IL-27R (also called WSX-1 and TCCR) and the gp130 chain of IL-6”
• IL-17 and Th17 Cells. (2009, background): “IL-27 was initially described as inducing T-bet and enhancing Th1 responses (218), but IL-27 also has dominant antiinflammatory properties (219).”
• Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases. (2016, background): “The p28 chain is related to IL-12p35, whereas the EBI3 chain is related to IL-12p40 and structurally resembles soluble IL-6R (Fig 1).(123) IL-27 is expressed predominantly by DCs and macrophages and endothelial cells.”
• Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10 (2007, background): “IL-27, a heterodimeric cytokine composed of the subunits EBI3 and p28 (ref”
• Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. (2007, background): “However, as discussed below, other studies with EAE have found that IL-27R knockout (KO) mice are more susceptible to disease (52), and initial reports with p28 note that it did not stimulate significant T cell proliferation or IFN-γ production (4).”
• The IL-23/Th17 axis in the immunopathogenesis of psoriasis. (2009, background): “Likewise, IL-27, belonging to the IL-6 family (Pflanz et al., 2002), also acts as a Th17 inhibitor, consistent with its capacity to drive a Th1 cell response (Batten et al., 2006; Stumhofer et al., 2006).”
• Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system (2006, background): “IL-27, a heterodimeric cytokine composed of Epstein-Barr virus–induced gene 3 (EBI3) and p28, signals through a receptor complex composed of the IL-27 receptor (IL-27R; also called WSX-1 and TCCR) and gp130 (refs”