TH-17 cells in the circle of immunity and autoimmunity

By E. Bettelli, M. Oukka, V. Kuchroo. Nature Immunology, 2007

1,321 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/28f0f08a5592283e0bf741523024d85a90a785fa

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Jetten
2. C. Dong
3. Shimon Sakaguchi
4. D. Sansom
5. L. Walker
6. Yeonseok Chung
7. Xuexian O. Yang
8. Hua Yu

Citations in the corpus

• Prostate cancer and inflammation: the evidence (2012, background): “Th17 cells are thought to be the key mediators in a number of autoimmune diseases, and may play a role in inflammation-associated cancer.(98,99) The role of Th17 cells in cancer is currently a topic of significant debate, as there appear to be conflicting reports as to whether Th17 cells promote car”
• Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation (2008, background): “6 and S12), IL-6 may render responder T cells resistant to Treg suppression depending on the amount of IL-6 produced by DCs, and also facilitate the differentiation of naı̈ve T cells to Th17 cells (35, 36).”
• T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. (2008, background): “A novel TH subset, termed THIL-17, TH17 or inflammatory TH (THi), has been recently identified as a distinct TH lineage (Bettelli et al., 2007; Dong, 2006; Reiner, 2007; Weaver et al., 2006).”
• Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis (2010, background): “Recent insights into the TH17/IL-17 biology from these models have led to the hypothesis that the effects of TH17 cells and their signature cytokine IL-17A can more profoundly explain T cell–dependent pathobiology in these models, replacing the TH1 paradigm, in which TH1 cytokines are the paramount ”
• 1,25-dihydroxyvitamin D3 and interleukin-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3 (2009, background): “Recently, additional CD4 T cell lineages including IL-17-secreting T cells (Th17), regulatory T cells (Tregs),(3) and T follicular helper cells (TFH) have been identified, which arise in response to T cell activation under appropriate conditions (2, 3).”
• TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression (2010, background): “In addition, TGF-β, together with IL-6, induces Th-17 cells [25,32,33].”