Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

By J. Stumhofer, J. Silver, A. Laurence, Paige M. Porrett, Tajie H. Harris, L. Turka, M. Ernst, C. Saris, J. O’Shea, Christopher A. Hunter. Nature Immunology, 2007

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Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset (2008, background): “However, IL-10 is not restricted to the T H -2 lineage but is also induced in all other CD4 + T cell subset”
The composition and signaling of the IL-35 receptor are unconventional (2012, background): “and blocking T H 17 differentiation and the TGF-β-driven formation of induced T reg cells and IL-10 productio”
Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent (2010, result): “Similar to previ ous studies (McGeachy et al., 2007; Stumhofer et al., 2007), IL10 was often coexpressed with IL17A and RoRt, sug gesting that Th17 cells may develop into IL10–secreting cells to limit Th17 effector function.”
Th17 cells express interleukin-10 receptor and are controlled by Foxp3− and Foxp3+ regulatory CD4+ T cells in an interleukin-10 dependent manner (2011, background): “The cytokines responsible for the differentiation of Th17 cells are already well defined; IL-6, TGF-b, and IL-1b are known to drive Th17 cell differentiation (Bettelli et al., 2006; Mangan et al., 2006; Sutton et al., 2006; Veldhoen et al., 2006).”