Toll-like receptor 4 polymorphisms and atherogenesis.

By G. Cooke, S. Segal, A. Hill. New England Journal of Medicine, 2002

650 citations recorded by the source corpus.

Subfields: Immunology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/ecbf055b6d3ad052e9c98b076b459f8ef8d1c658

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Shizuo Akira
2. L. Zitvogel
3. Luke A. O'Neill
4. M. Karin
5. T. Lawrence
6. G. Hotamışlıgil
7. R. Medzhitov
8. V. Nizet

In Nutrition and Dietetics

1. P. Noble
2. Ruth E. Ley
3. Rob Knight
4. Jiurong Liang
5. F. Bäckhed
6. D. Jiang
7. Luke A. O'Neill
8. G. Hotamışlıgil

Citations in the corpus

• Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe −/− Mice (2016, background): “A positive correlation between serum lipopolysaccharide-binding protein level and carotid intima thickness and an association of Toll-like receptor 4 polymorphisms with decreased atherosclerosis have been found in humans.(43,44) Toll-like receptor 4 is expressed in various vascular cells, including ”
• Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. (2006, background): “Furthermore, polymorphisms in the human TLR4 locus have been associated with atherogenesis (Kiechl et al., 2002), and polymorphisms in a TLR gene cluster encoding TRL1, TLR6, and TLR10 were linked to increased prostate cancer risk (Sun et al.”
• Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2 (2003, background): “These studies also provide a mechanism for the association of polymorphisms in the TLR genes with the development of vascular disease (25).”
• A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease (2003, background): “Recent analyses with TLR4 SNPs suggest a PAMP-specific influence of this gene on infectious disease susceptibility because TLR4 is associated with gram-negative bacterial infections (7, 8, 10, 11).”
• Negative regulation of Toll-like receptor-mediated immune responses (2005, result): “, consistent with the finding that patients with a D299G polymorphism of TLR4 have reduced risk of atherosclerosi”
• CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer (2009, background): “We therefore tested whether fibrillar β-amyloid peptide (1-42) (Aβ1-42) could activate TLR4-TLR6 signaling via CD36.”
• Innate and acquired immunity in atherogenesis (2002, background): “, a TLR4 polymorphism that attenuates receptor signaling is associated with decreased atherosclerosis in human”
• The Interleukin-1 Receptor/Toll-Like Receptor Superfamily: Signal Transduction During Inflammation and Host Defense (2000, background): “A recently characterized polymorphism in human TLR-4 (Asp299Gly), which renders individuals more susceptible to severe bacterial infections, has been associated with decreased risk of atherosclerosis (109).”
• Toll-like receptors in systemic autoimmune disease (2006, background): “A variant of TLR4 with reduced function has been shown to confer reduced risk of developing atherosclerosi”
• Human oral, gut, and plaque microbiota in patients with atherosclerosis (2010, background): “Furthermore, polymorphism in Tlr4, which promotes production of proinflammatory cytokines in response to bacterial LPS, is associated with lower levels of proinflammatory cytokines, acute-phase reactants, carotid atherosclerosis, and a smaller intima-media thickness in the common carotid artery (39)”
• Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy (2007, background): “Relevance of a TLR4 mutant for chemotherapy efficacy A sequence polymorphism in Tlr4 (896A/G, Asp299Gly, rs4986790) affecting the extracellular domain of TLR4 is associated with reduced endotoxin responses and with a reduced susceptibility to cardiovascular disease in human”
• Hyaluronan as an Immune Regulator in Human Diseases (2011, positive): “This finding pointed to the notion that innate immunity plays a role in atherogenesis (209).”