Human oral, gut, and plaque microbiota in patients with atherosclerosis

By Omry Koren, A. Spor, Jenny E Felin, F. Fåk, Jesse Stombaugh, V. Tremaroli, C. Behre, Rob Knight, B. Fagerberg, Ruth E. Ley and 1 more. Proceedings of the National Academy of Sciences of the United States of America, 2010

1,140 citations recorded by the source corpus.

Subfields: Molecular Biology, Periodontics

View Paper: https://www.semanticscholar.org/paper/fae078d2c06ccca7bd8901e7c94602ada25ecb5a

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Citations in the corpus

Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis (2015, background): “Nonetheless, the gut microbiome is known to be remarkably dynamic and adaptive, including changes in response to different dietary inputs, as well as the presence versus absence of distinct diseases (Cox et al., 2014; Koren et al., 2011; Wu et al., 2011).”
Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe −/− Mice (2016, background): “Bacterial DNA from the gut microbiota has been detected in human atherosclerotic plaques.(13) However, direct evidence for the causative role of altered gut microbiota (dysbiosis) in the pathogenesis of atherosclerosis is still lacking.”
Metabolic Reconstruction for Metagenomic Data and Its Application to the Human Microbiome (2012, background): “Although these are within the range of false positives expected at this level of stringency, recent observations of the gut microbiota in atherosclerosis [57] have also detected borderline significant shifts in organismal composition.”
The Hologenome Concept: Human, Animal and Plant Microbiota (2014, background): “This hypothesis was reinforced by the finding of bacterial DNA, primarily from oral microbiota (Chryseomonas, Veillonella and Streptococcus), but also gut bacteria, in atherosclerotic plaques (Koren et al. 2011).”
The human microbiome (2017, background): “These two seemingly unrelated diseases may be linked by microbiota, as the types and abundance of bacteria in atherosclerotic plaques correlated with the abundance of those same bacteria in the oral cavity [38].”
Immunity, atherosclerosis and cardiovascular disease (2013, result): “Another interesting development, in which infections and atherosclerosis/CVD could be related in a more indirect way, is recent findings implicating the intestinal bacterial flora [74,75].”
Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease (2020, background): “Gut dysbiosis contributes to dysregulated bile acid metabolism (687), leading to hyperlipidemia and hyperglycemia (688, 689).”
Proteobacteria: A Common Factor in Human Diseases (2017, background): “In this context, there is evidence that high levels of Proteobacteria are present within the atherosclerotic plaque [47]; thus it can be speculated that these microorganisms may have proinflammatory effects that may contribute to the activation of the plaque.”
Dietary lipids, gut microbiota and lipid metabolism (2019, background): “By analyzing the microbial composition of atherosclerotic plaques, fecal samples and the oral cavity in patients with symptomatic carotid artery stenosis [40], Koren et al observed shared operational taxonomic units (OTUs) between all three sites, consistent with the possibility that oral and gastro”
Oral microbiomes: more and more importance in oral cavity and whole body (2018, background): “identified Chryseomonas, Veillonella and Streptococcus in the majority of atherosclerotic patients’ oral mocrobiomes (Koren et al., 2011).”
Gut Microbiota in Cardiovascular Health and Disease (2017, background): “to gut microbiota, taxa characteristics of oral microbiota have also been detected in atherosclerotic plaque in humans.(3) Given”