The Interleukin-1 Receptor/Toll-Like Receptor Superfamily: Signal Transduction During Inflammation and Host Defense

By A. Dunne, Luke A. O'Neill. Science's STKE, 2000

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Interleukin-1 and neuronal injury (2005, background): “The IL-1 and IL-18 receptors belong to the IL-1 receptor and Toll-like receptor (TLR) superfamily, which has a crucial role in the innate immune respons”
LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF (2003, background): “The TLR3- and TLR4-restricted utilization of IRF-inducing adaptor molecules such as TRAM and TRIF induces not only the cytokines, costimulatory molecules, and antimicrobial peptides that are induced by all TLRs but also anti–viral type I interferons and specific chemokines including IP-10 and RANTES”
IL‐1β mediated up‐regulation of HIF‐lα via an NFkB/COX‐2 pathway identifies HIF‐1 as a critical link between inflammation and oncogenesis (2003, background): “IL-1β attracts and activates immune cells and controls the expression of most immunomodulatory genes (6).”
SIGIRR, a negative regulator of Toll-like receptor–interleukin 1 receptor signaling (2003, background): “These molecules signal through similar, although not identical, signaling pathways to activate the transcription factors nuclear factor (NF)-κB and activating protein 1 (AP-1”
Toll-like receptor signalling (2004, neutral): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7189">TRAF6”
The interleukin‐1 receptor/Toll‐like receptor superfamily: 10 years of progress (2008, background): “There are 24 members of the IL-1R/TLR superfamily (38).”