Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model

By L. Björklund, R. Sánchez-Pernaute, Sangmi Chung, Therese Andersson, Iris Y. Chen, K. McNaught, A. Brownell, B. Jenkins, Claes Wahlestedt, Kwang-Soo Kim and 1 more. Proceedings of the National Academy of Sciences of the United States of America, 2002

1,226 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/eca46ce68829c2cd5437344bdb02a895a88f43f9

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Citations in the corpus

Missing pieces in the Parkinson's disease puzzle (2010, background): “Recently, there has been great interest in human stem cells, which have been shown to survive, innervate to some extent, and reverse motor dysfunction in rodent and monkey models of Parkinson's diseas”
Functional engraftment of human ES cell–derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes (2006, background): “The acquisition of more highly enriched dopaminergic populations is an important prerequisite to using HES cell–derived dopaminergic neurons for cell-based therapy, as non-dopaminergic neuronal derivatives may yield unpredictable or deleterious neurological side-effects, and incompletely differentia”
Stem cell therapy for human neurodegenerative disorders–how to make it work (2004, background): “Implantation of mouse ESCs into rat striatum caused teratomas in 20% of the animal”
Neural induction, the default model and embryonic stem cells (2002, result): “In further support of these results, a second study showed that dilution of mouse ES cells into single-cell suspensions resulted in a higher number of neural cells, which became dopamine-producing neurons, integrated into a host rat striatum and rescued a rat model of Parkinson's diseas”
Parkinson's Disease Mechanisms and Models (2003, background): “Only nonplantation or gene therapy to repair the damaged path-human primates accurately mimic the motor symptoms ways (Bjorklund et al., 2002).”
The tumorigenicity of human embryonic and induced pluripotent stem cells (2011, background): “Indeed, treatment attempts with embryonic stem cells in animal models were shown to be fatal owing to the formation of teratoma-like tumour”
Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease (2002, background): “For example, tumour formation is a problem associated with ES cell grafting in models of Parkinson's diseas”
Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient (2009, background): “The injection of pluripotent ESC or ESC-derived precursor cells in rodents leads frequently to the development of teratomas or teratocarcinomas [6,11,12], although the tumorigenic potential of ESC seems to be greatly reduced when cells are predifferentiated in vitro before implantation [7,8,13].”