Stem cell therapy for human neurodegenerative disorders–how to make it work

By O. Lindvall, Z. Kokaia, A. Martínez-Serrano. Nature Medicine, 2004

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Distinct Mammalian Precursors Are Committed to Generate Neurons with Defined Dendritic Projection Patterns (2007, background): “In recent years, there has been a surge in interest in the possibility of using different types of stem cells for cell replacement therapies aimed at correcting neurological disorders caused by neuronal loss, such as stroke and Parkinson, Huntington and Alzheimer diseases [”
A Long‐Term Follow‐Up Study of Intravenous Autologous Mesenchymal Stem Cell Transplantation in Patients With Ischemic Stroke (2010, background): “promote this process [7] [11] [21] [22].”
Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism (2005, methodology): “(MP Biomedicals) and then injected intravenously into (1) C57BL/6 mice that”
Stem cells for the treatment of neurological disorders (2006, background): “Clinical trials of the transplantation of human fetal dopaminergic neurons have shown that cell replacement can produce major, long-lasting improvement in some patient”
Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient (2009, background): “However, there are potential dangers associated with stem cell therapy, such as malignant transformation [2,3].”