Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease

By Jong-Hoon Kim, J. Auerbach, J. A. Rodríguez-Gómez, I. Velasco, Denise K Gavin, N. Lumelsky, Sang‐Hun Lee, John Nguyen, R. Sánchez-Pernaute, K. Bankiewicz and 1 more. Nature, 2002

1,665 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/dc811b3e50ee902fbe6901404e16c01252dfffea

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease (2008, methodology): “Following protocols developed for mouse ES cells, we treated FGF2 responsive, iPS cell-derived neural precursor cells with the regional patterning factors sonic hedgehog and FGF8 (23, 27).”
Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain (2004, background): “In rodents, circling has been linked to striatal neurodegeneration in Huntingtin transgenics (Hodgson et al., 1999) and to drug-induced defects of dopamine supply to the striatum (Kim et al., 2002), indicating the involvement of the basal ganglia-thalamo-cortical circuitry (see Wang et al., 2002).”
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor (2004, positive): “HESCs could also be used to generate specific types of tissues for cell replacement therapy as a promising approach to treatment of devastating diseases such as Parkinson disease and diabetes mellitu”
Directed differentiation of telencephalic precursors from embryonic stem cells (2005, background): “This is the first quantitative report of such efficient in vitro induction of telencephalic precursors from ES cells (qualitative detection of Bf1 induction has also been reporte”
Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis (2003, background): “This pathological feature prevents the use of a classical neural transplantation approach, in which the therapeutic cells are injected in the proximity of the site of the lesion or into its target area, such as in Parkinson's diseas”
Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation (2005, background): “…neurons incorporate into the striatum and improve behavioral performance following transplantation into mouse models of Parkinson’s disease (Kim et al., 2002; Nishimura et al., 2003), and mouse embryonic stem cell-derived motor neurons survive and differentiate following transplantation…”
Stem cell therapy for human neurodegenerative disorders–how to make it work (2004, background): “One advantage with stem cells is the possibility for controlled genetic modification, which, for example, could be used to increase survival, differentiation, migration and function of their progen”
Mesenchymal stem cells: clinical applications and biological characterization. (2004, background): “Embryonic stem cells are capable of forming dopamine neurons in an animal model of Parkinson’s Disease ( Kim et al., 2002 ).”
Embryonic stem cell differentiation: emergence of a new era in biology and medicine. (2005, background): “For instance, midbrain dopaminergic neurons have been generated in the EB system by overexpression in the cells of the transcription factor nuclear-receptor-related factor1 (Nurr1), and the addition to the cultures of SHH and FGF8 (Kim et al. 2002).”
Embryonic stem cells: prospects for developmental biology and cell therapy. (2005, methodology): “Importantly, it is not simply the transplantation of mouse (396) and human (362) ES cells that results in the growth of teratomas, but also the transplantation of ES-derived differentiated cell populations (38, 191).”