Parkinson's Disease Mechanisms and Models

By W. Dauer, S. Przedborski. Neuron, 2003

5,377 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/76bdf4d207c09c6c15c4b2e16baf04380ca902c6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. H. Ko
2. Valina L. Dawson
3. T. Dawson
4. A. Schober
5. Kent C. Berridge
6. J. Bové
7. C. Perier
8. Delphine Prou

In Neurology

1. H. Ko
2. Valina L. Dawson
3. T. Dawson
4. J. Bové
5. C. Perier
6. A. Schober
7. Kent C. Berridge
8. Delphine Prou

Citations in the corpus

• The mitophagy pathway and its implications in human diseases (2023, background): “The main manifestations are increased muscle tension throughout the body, slow movements, and dull facial expressions, often accompanied by static tremors.(179) The occurrence of PD is correlated with mutations in some key proteins, like α-Synuclein (α-syn),(180) leucine-rich repeat kinase 2 (LRRK2)”
• Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology (2008, background): “PD cases are referred as familial (FPD) or idiopathic (IPD) depending on whether the disease is hereditary (FPD) or from unknown origin, possibly due to environmental exposure to neurotoxicants (IPD) (Dauer and Przedborski, 2003; Samii et al., 2004).”
• Excitotoxicity: bridge to various triggers in neurodegenerative disorders. (2013, background): “Cl entry has been shown to be a key mediator of the acute excitotoxicity marked by somatic and dendritic swelling (Dauer and Przedborski, 2003; Mancuso et al., 2010; Shepherd et al., 2009; Woolley et al., 2011; Clement et al., 2012).”
• Parkinson's disease: genetics and pathogenesis. (2011, background): “Other toxins, including 6hydroxydopamine (126), rotenone (127), and paraquat (128), can also produce relatively selective loss of dopaminergic neurons.”
• Toxin-induced models of Parkinson’s disease (2005, methodology): “Although a host of natural and synthetic molecules do exert deleterious effects on dopaminergic neurons, only a handful are used in living laboratory animals to recapitulate some of the hall- marks of PD.”
• Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond (2009, background): “Indeed, in multiple system atrophy (MSA), whose clinical presentation includes Parkinsonism, ataxia, and autonomic failure, -synuclein–containing inclusions are actually more prominent in oligodendrocytes (for review see Dauer and Przedborski, 2003).”
• The mitochondrial energy transduction system and the aging process. (2007, background): “Reduced complex I activity predisposes to excitotoxicity by altering ATP levels and by impairing Ca(2) homeostasis (45).”
• Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. (2008, methodology): “To address this issue, we conducted in vivo experiments using the well-characterized MPTP-intoxicated mouse model of PD (1).”
• Oxidative stress in neurodegenerative diseases (2012, background): “In PD, dopaminergic neurons of the substantia nigra are the primary neurons undergoing cell death [26] .”
• Α-synuclein misfolding and Parkinson's disease. (2012, background): “limited understanding of the key molecular events provoking neurodegeneration, are among the major reasons determining the lack of drugs for the successful inhibition and cure of these diseases [444].”