Missing pieces in the Parkinson's disease puzzle

By Jose A. Obeso, M. Rodríguez-Oroz, C. Goetz, C. Marín, J. Kordower, Manuel Rodríguez, E. Hirsch, M. Farrer, A. Schapira, G. Halliday. Nature Medicine, 2010

765 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/cdf2148a2fe06f6183007801b5262f59cfcceb4c

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In Cellular and Molecular Neuroscience

In Neurology

Terrence J. Sejnowski

Citations in the corpus

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice (2018, neutral): “Although -synuclein pathology is now considered central to the spread of disease pathophysiology in clinical PD, there is also a strong clinical and experimental evidence for mitochondrial dysfunction, oxidative stress, and proteasomal impairment as key mechanisms that can initiate and drive dopami”
Collection and Analysis of a Parkinson Speech Dataset With Multiple Types of Sound Recordings (2013, background): “When the patient arrives at the hospital, his/her demographic information including gender, age [23], [24], profession, educational status, and a brief health history including the chronic diseases, smoking rate, permanently used drugs, and symptoms of diseases are recorded.”
The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's disease (2013, background): “Thus SNc dopamine neurons, particularly in humans, whose axons we estimate to give rise to more than 1 million synapses and have a total length exceeding 4 m, are at a distinct disadvantage with respect to energy balance which may be a factor in their selective vulnerability in PD. Keywords: dopamin”
Role of Oxidative Stress in Parkinson's Disease (2013, background): “Aging is an obvious factor associated with the onset of PD, and failure of normal cellular processes that occurs with aging is believed to cause increased vulnerability of DAergic neurons [2].”
Oxidative Stress: A Key Modulator in Neurodegenerative Diseases (2019, background): “It is also believed that ageing plays a pivotal role in PD, as with ageing, normal cellular processes are more prone to ceasing, which leads to degeneration of DAergic neurons [96,97].”