Signaling by IL‐12 and IL‐23 and the immunoregulatory roles of STAT4

By W. Watford, B. Hissong, J. Bream, Y. Kanno, L. Muul, J. O’Shea. Immunological Reviews, 2004

608 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/ebc75506238a9f2a6e781181a3d25ba197070238

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In Immunology

1. J. O’Shea
2. A. Laurence
3. Christopher A. Hunter
4. C. Tato
5. A. Yoshimura
6. T. Hirano

In Oncology

1. J. O’Shea
2. A. Laurence
3. Christopher A. Hunter
4. A. Yoshimura

Citations in the corpus

• Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. (2006, background): “Antibodies and Cytokines The mAbs for the N-terminal region (aa 46–258) of human Tyk2, IL12Rb1, IL-12Rb2, IkBa, IL-4, and IFNg were purchased from BD Pharmingen, and the CD3 mAb (OKT3) was from Janssen Pharmaceutical.”
• TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1 (2007, background): “IL-27 inhibits T H 17 via IFN-γ/STAT1-dependent mechanisms IL-27 mediates its biological effects through the activation of STAT1 and STAT3 pathway”
• IL-12 p40 monomer is different from other IL-12 family members to selectively inhibit IL-12Rβ1 internalization and suppress EAE (2020, background): “While IL-12 signals via a heterodimer of IL-12Rβ1 and IL-12Rβ2, IL-23 utilizes a heterodimer of IL-12Rβ1 and IL-23R for functioning (19, 20).”
• A cytokine-mediated link between innate immunity, inflammation, and cancer. (2007, unknown): “IL-12 and IL-23 belong to the IL-12 family of proinflammatory heterodimeric cytokines and are composed of IL-12p40/IL-12p35 and IL-12p40/IL-23p19 subunits, respectively (81).”
• Janus kinases in immune cell signaling (2009, background): “A recent experimental report showed that the production of IL-17 by cd T cells in an infectious model of Escherichia coli was impaired in Tyk2 KO mice, without affecting IL-23 levels but IL-23-mediated IL-17 induction (55).”
• Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system (2006, result): “That conclusion is supported by the finding of enhanced development of T H -17 cells in vivo in Stat1 −/− mic”