TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1
By A. Amadi-Obi, C. Yu, Xuebin Liu, R. Mahdi, Grace Clarke, R. Nussenblatt, I. Gery, Y. Lee, C. Egwuagu. Nature Medicine, 2007
809 citations recorded by the source corpus.
Subfields: Immunology, Ophthalmology, Rheumatology
View Paper: https://www.semanticscholar.org/paper/624106f7ef4ada2837c7a398d16f6440cb2f4dff
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Citations in the corpus
- IL-2 Family Cytokines: New Insights into the Complex Roles of IL-2 as a Broad Regulator of T helper Cell Differentiation (2011, background): “In addition to its inhibition of Th17 differentiation, IL-2 can also expand IL-17-producing cells once generated [50 ], indicating complex roles of IL-2 in the regulation of IL-17.”
- Th17 cells in human disease (2008, background): “In humans with non-VKH uveitis, Th17 cells were found in the peripheral blood at levels directly correlating to disease activity (25).”
- Differentiation of Effector CD4 T Cell Populations (2010, positive): “On the other hand, STAT5 suppresses Th17 cell differentiation (107) but is required for the expansion of differentiated Th17 cells (130).”
- A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses (2008, methodology): “; the use of exogenous IL-2, which produces population expansion of differentiated T H -17 cell”
- Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis (2011, background): “…El-behi et al., 2009; Villarino et al., 2010) and humans (Diveu et al., 2009; Liu and RohowskyKochan, 2011), through a mechanism dependent on STAT1 (Amadi-Obi et al., 2007; Batten et al., 2006; Diveu et al., 2009; Liu and Rohowsky-Kochan, 2011; Stumhofer et al., 2006; 1642 Human STAT1 activating…”
- Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10 (2007, background): “, IL-27 has been subsequently reported to limit T H 1, T H 2 and T H -17 responses in various models of infection and autoimmunit”
- Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy (2013, positive): “…HIV-1 maintain peripheral Th17 cell numbers when treated with IL-2 (Ndhlovu et al., 2010), and IL-2 can expand Th17 cells once generated, which helps to explain benefits of anti-IL-2 receptor-based immunotherapy in uveitis and scleritis, where Th17 cells are pathogenic (Amadi-Obi et al., 2007).”
- New insights into the regulation of T cells by γc family cytokines (2009, neutral): “Although IL-2 inhibits T H 17 cell differentiation, it can provide proliferative signals to human T H 17 cells, as shown by the IL-2-induced in vitro proliferation of T H 17 cells from normal donors and from patients with uveitis or scleriti”