Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity.

By Y. Minegishi, M. Saito, T. Morio, Ken Watanabe, K. Agematsu, S. Tsuchiya, H. Takada, T. Hara, N. Kawamura, T. Ariga and 26 more. Immunity, 2006

696 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/8c97c3ec73ca7399d8632a8f8ee5be34f0f903ed

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. J. O’Shea
2. A. Laurence
3. P. Murray
4. I. McInnes

In Oncology

1. J. O’Shea
2. A. Laurence
3. P. Murray
4. I. McInnes
5. S. Gaffen

Citations in the corpus

• The JAK/STAT signaling pathway: from bench to clinic (2021, background): “Thus, Tyk2 does not seem necessary for type I interferon signal transduction.(50) Moreover, Tyk2 regulates the balance of Th1 and Th2 cells in mice and regulates the allergic reaction mediated by Th2 cells.”
• The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention (2015, background): “STAT3 is also important for CD8 T cell memory, so patients with HIES are prone to recurrent Varicella zoster and Epstein-Barr virus infections (13).”
• The JAK-STAT Signaling Pathway: Input and Output Integration1 (2007, positive): “In contrast, human TYK2 seems to be essential for signaling through a broader range of cytokine receptors (17).”