A Special Population of Regulatory T Cells Potentiates Muscle Repair
By Dalia Burzyn, Wilson Kuswanto, D. Kolodin, J. Shadrach, M. Cerletti, Y. Jang, Esen Sefik, T. G. Tan, A. Wagers, C. Benoist and 1 more. Cell, 2013
1,148 citations recorded by the source corpus.
SUMMARY Long recognized to be potent suppressors of immune responses, Foxp3+CD4+ regulatory T (Treg) cells are being rediscovered as regulators of nonimmunological processes. We describe a phenotypically and functionally distinct population of Treg cells that rapidly accumulated in the acutely injured skeletal muscle of mice, just as invading myeloidlineage cells switched from a proinflammatory to a proregenerative state. A Treg population of similar phenotype accumulated in muscles of genetically dystrophic mice. Punctual depletion of Treg cells during the repair process prolonged the proinflammatory infiltrate and impaired muscle repair, while treatments that increased or decreased Treg activities diminished or enhanced (respectively) muscle damage in a dystrophy model. Muscle Treg cells expressed the growth factor Amphiregulin, which acted directly on muscle satellite cells in vitro and improved muscle repair in vivo. Thus, Treg cells and their products may provide new therapeutic opportunities for wound repair and muscular dystrophies.
Subfields: Immunology, Rehabilitation
View Paper: https://www.semanticscholar.org/paper/8a5ab27858262ec2ac988513704595f9e3f7a0d1
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In Immunology
Citations in the corpus
- Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells (2016, background): “, 2012) or regulation of tissue repair in skeletal muscle (Burzyn et al., 2013) and in lung tissue (Arpaia et al.”
- Regulatory T cells in Skin Facilitate Epithelial Stem Cell Differentiation (2017, positive): “…would be preferentially expressed in skin Tregs when compared to Tregs found in SDLNs. Consistent with heightened activation of Tregs in tissues (Burzyn et al., 2013; Feuerer et al., 2009; Sanchez Rodriguez et al., 2014), differential expression analyses revealed increased abundance of genes…”